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Electrospun nanofibers of collagen-chitosan and P(LLA-CL) for tissue engineering |
| MO Xiumei1, CHEN Zonggang1, Hans J. Weber2 |
| 1.Institute of Biological Science and Biotechnology, Donghua University, Shanghai 201620, China; 2.Department of Biomedical Engineering, Aachen University of Applied Sciences, Ginsterweg 1, D-52428 Juelich, Germany |
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Abstract Electrospun nanofibers could be used to mimic the nanofibrous structure of the extracellular matrix (ECM) in native tissue. In tissue engineering, the ECM could be used as tissue engineering scaffold to solve tissue engineering problems. In this paper, poly(L-lactid-co-ε-caprolactone) [P(LLA-CL)] nanofibers and collagen-chitosan complex nanofibers were fabricated by electrospinning. Results of the experiments showed that the mechanical properties of the collagenchitosan complex nanofibers varied with the collagen content in the complex. It was also found that the biodegradability of P(LLA-CL) nanofibers was faster than its membrane and that smooth muscle cells (SMC) grow faster on collagen nanofibers than on P(LLA-CL) nanofibers.
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Issue Date: 05 March 2007
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