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Frontiers of Materials Science

ISSN 2095-025X

ISSN 2095-0268(Online)

CN 11-5985/TB

Postal Subscription Code 80-974

2018 Impact Factor: 1.701

Front. Mater. Sci.    2008, Vol. 2 Issue (2) : 172-178    https://doi.org/10.1007/s11706-008-0029-1
Microsphere-integrated gelatin-siloxane hybrid scaffolds for bone tissue engineering: bioactivity & antibacterial activity
WANG Lin1, YU Bing1, SUN Li-ping1, REN Lei1, ZHANG Qi-qing2
1.Research Center of Biomedical Engineering, College of Materials, Xiamen University; 2.Research Center of Biomedical Engineering, College of Materials, Xiamen University;Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College
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Abstract Microsphere integrated gelatin-siloxane hybrid scaffolds were successfully synthesized by using a combined sol-gel processing, post-gelation soaking and freeze-drying process. A bone-like apatite layer was able to form in the Ca2+-containing porous hybrids upon soaking in a simulated body fluid (SBF) up to 1 day. The rate of gentamicin sulfate (GS) release from the GS-loaded gelatin-siloxane hybrid microsphere became constant after a 4 h burst. The antibacterial activity was assessed by the agar diffusion test (ADT) and the bactericidal effect test. It is evident that the as-synthesized porous scaffolds have excellent bioactivity and antibacterial activity, and may be favorable in bone tissue engineering.
Issue Date: 05 June 2008
 Cite this article:   
YU Bing,WANG Lin,SUN Li-ping, et al. Microsphere-integrated gelatin-siloxane hybrid scaffolds for bone tissue engineering: bioactivity & antibacterial activity[J]. Front. Mater. Sci., 2008, 2(2): 172-178.
 URL:  
https://academic.hep.com.cn/foms/EN/10.1007/s11706-008-0029-1
https://academic.hep.com.cn/foms/EN/Y2008/V2/I2/172
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