β-Cyclodextrin inclusion complex: preparation, characterization, and its aspirin release <italic>in vitro

doi:10.1007/s11706-012-0176-2

Front Mater Sci

2012, Vol. 6

Issue (3) : 259-267 https://doi.org/10.1007/s11706-012-0176-2

RESEARCH ARTICLE

β-Cyclodextrin inclusion complex: preparation, characterization, and its aspirin release in vitro

Hui-Yun ZHOU(

), Ling-Juan JIANG, Yan-Ping ZHANG, Jun-Bo LI

The Chemical Engineering & Pharmaceutics College, Henan University of Science and Technology, Luoyang 471003, China

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Abstract

In this work, the optimal clathration condition was investigated for the preparation of aspirin–β-cyclodextrin (Asp--β-CD) inclusion complex using design of experiment (DOE) methodology. A 3-level, 3-factor Box--Behnken design with a total of 17 experimental runs was used. The Asp--β-CD inclusion complex was prepared by saturated solution method. The influence on the embedding rate was investigated, including molar ratio of β-CD to Asp, clathration temperature and clathration time, and the optimum values of such three test variables were found to be 0.82, 49°C and 2.0 h, respectively. The embedding rate could be up to 61.19%. The formation of the bonding between--COOH group of Asp and O--H group of β-CD might play an important role in the process of clathration according to FT-IR spectra. Release kinetics of Asp from inclusion complex was studied for the evaluation of drug release mechanism and diffusion coefficients. The results showed that the drug release from matrix occurred through Fickian diffusion mechanism. The cumulative release of Asp reached only 40% over 24 h, so the inclusion complex could potentially be applied as a long-acting delivery system.

Keywords β-cyclodextrin (β-CD) aspirin (Asp) saturated solution method Box--Behnken design release kinetics

Corresponding Author(s): ZHOU Hui-Yun,Email:zhouhuiyun@hotmail.com

Issue Date: 05 September 2012

Cite this article:

Hui-Yun ZHOU,Ling-Juan JIANG,Jun-Bo LI, et al. β-Cyclodextrin inclusion complex: preparation, characterization, and its aspirin release in vitro[J]. Front Mater Sci, 2012, 6(3): 259-267.

URL:

https://academic.hep.com.cn/foms/EN/10.1007/s11706-012-0176-2
https://academic.hep.com.cn/foms/EN/Y2012/V6/I3/259

Tab.1 Experimental range and levels of independent variables

Tab.2 Design matrix in the Box–Behnken model, observed response and predicted values

Fig.1 Content data of Asp of the inclusion complex.

Tab.3 ANOVA analysis for the BBD design

Tab.4 Regression analysis for the BBD design

Fig.2 The effects of mutual interactions between molar ratio and temperature on embedding rate.

Fig.3 The effects of mutual interactions between molar ratio and time on embedding rate.

Fig.4 The effects of mutual interactions between temperature and time on embedding rate.

Fig.5 FT-IR spectra of β-CD (a), physical mixture (b), inclusion complex (c), and Asp (d).

Fig.6 Cumulative release of Asp from different samples in pH 6.8 PBS at 37°C (date shown were the mean±S.D., = 3).

Tab.5 Results from kinetics of drug release for different models

Fig.7 Cumulative percentage release . square root of time in hours.

Fig.8 Logarithm of cumulative percentage release . logarithm of time in hours.

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