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Synthesis strategies for disulfide bond-containing polymer-based drug delivery system for reduction-responsive controlled release |
Lei LIU,Peng LIU( ) |
| State Key Laboratory of Applied Organic Chemistry and Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China |
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Abstract Tumor micro-environment responsive drug delivery systems (DDSs) have been developed as a potential approach to reduce the side effects of cancer chemotherapy. Glutathione (GSH) has been supposed to the most significant signal of the difference between the normal tissue and the tumor cells, besides the media pH and temperature. In recent years, the reduction-responsive DDSs have attracted more and more attention for delivery of anti-cancer drugs, based on such physiological signal. Among them, disulfide bond-containing polymers have been designed as the main tool for the purpose. The recent progress in the synthesis strategies for the disulfide bond-containing polymer-based DDS is focused in the present review.
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| Keywords
drug delivery system (DDS)
reduction-responsive
disulfide bond-containing polymer
tumor micro-environment responsive
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Corresponding Author(s):
Peng LIU
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Online First Date: 06 July 2015
Issue Date: 23 July 2015
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