Hollow mesoporous silica nanoparticles as nanocarriers employed in cancer therapy: A review

doi:10.1007/s11706-020-0526-4

Front. Mater. Sci.

2020, Vol. 14

Issue (4) : 373-386 https://doi.org/10.1007/s11706-020-0526-4

REVIEW ARTICLE

Hollow mesoporous silica nanoparticles as nanocarriers employed in cancer therapy: A review

Yimin ZHOU, Qingni XU, Chaohua LI, Yuqi CHEN, Yueli ZHANG, Bo LU(

)

School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan 430070, China

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Abstract

Hollow mesoporous silica nanoparticles (HMSNs) have become an attractive drug carrier because of their unique characteristics including stable physicochemical properties, large specific surface area and facile functionalization, especially made into intelligent drug delivery systems (DDSs) for cancer therapy. HMSNs are employed to transport traditional anti-tumor drugs, which can solve the problems of drugs with instability, poor solubility and lack of recognition, etc., while significantly improving the anti-tumor effect. And an unexpected good result will be obtained by combining functional molecules and metal species with HMSNs for cancer diagnosis and treatment. Actually, HMSNs-based DDSs have developed relatively mature in recent years. This review briefly describes how to successfully prepare an ordinary HMSNs-based DDS, as well as its degradation, different stimuli-responses, targets and combination therapy. These versatile intelligent nanoparticles show great potential in clinical aspects.

Keywords hollow mesoporous silica nanoparticles intelligent drug delivery system stimuli response targeting drug delivery combination therapy

Corresponding Author(s): Bo LU

Online First Date: 20 October 2020 Issue Date: 09 December 2020

Cite this article:

Yimin ZHOU,Qingni XU,Chaohua LI, et al. Hollow mesoporous silica nanoparticles as nanocarriers employed in cancer therapy: A review[J]. Front. Mater. Sci., 2020, 14(4): 373-386.

URL:

https://academic.hep.com.cn/foms/EN/10.1007/s11706-020-0526-4
https://academic.hep.com.cn/foms/EN/Y2020/V14/I4/373

Fig.1 Transmission electron microscopy images of (a) HMSNs with the core–shell structure [¹¹], (b) HMSNs with a hollow cavity [¹³], and (c) MSNs [¹⁵]. (Reproduced with permission from Refs. [¹¹,¹³,¹⁵])

Fig.2 Schematic diagram of therapeutic properties, morphology and degradation of PEG/rFeO_x-HMSN nanoparticle. (Reproduced with permission from Ref. [³⁵])

Fig.3 Schematic diagram for (a) construction of Schiff base-embedded silica nanoparticles, (b) preparation of prodrug nanoparticles based on S-MON, and (c) cell uptake and degradation of S-MON. (Reproduced with permission from Ref. [³⁷])

Fig.4 (a) Schematic diagram of the preparation route of DOX@HMSNs-SS-HA, (b) Mechanism of the DOX@HMSNs-SS-HA triggering drug release. (Reproduced with permission from Ref. [¹³])

Fig.5 Schematic diagram of the preparation of THMSNs@LMDI and the light-stimuli triggering drug release. (Reproduced with permission from Ref. [⁷⁶])

Fig.6 Synthesis route of hybrid-MSNs (top) and dual response triggering drug release from hybrid-MSNs (bottom). (Reproduced with permission from Ref. [⁸⁷])

Fig.7 Schematic diagram of the synthesis process of the bionic nanoreactor HMSNs-GO_x-Ce6@CPPO-PFC/O₂@C. (Reproduced with permission from Ref. [⁹⁸])

Fig.8 Schematic illustrations of the preparation of DOX/GO_x@HMSN-PEM and the pH-responsive drug release to achieve chemotherapy combined with starvation treatment. (Reproduced with permission from Ref. [⁵⁹])

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[1]	Hai WANG, Yu-Liang ZHAO, Guang-Jun NIE. Multifunctional nanoparticle systems for combined chemo- and photothermal cancer therapy[J]. Front Mater Sci, 2013, 7(2): 118-128.

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