Condensed Matter, Materials Physics, and Statistical Physics |
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Optimal aspect ratio of endocytosed spherocylindrical nanoparticle |
Ying-Bing Chen2,Yan-Hui Liu1,2,3( ),Yan Zeng4,Wei Mao2,Lin Hu2,Zong-Liang Mao2,Hou-Qiang Xu1,*( ) |
1. Key Laboratory of Animal Genetics, Breeding and Reproduction in the Plateau Mountainous Region Ministry of Education, College of Animal Science, Guizhou University, Guiyang 550025, China
2. Soft Condensed Matter Laboratory, College of Science, Guizhou University, Guiyang 550025, China
3. State Key Laboratory of Theoretical Physics, Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 100190, China
4. College of Civil Engineering, Guizhou University, Guiyang 550025, China |
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Abstract Recent simulations have demonstrated that bioparticle size and shape modulate the process of endocytosis, and studies have provided more quantitative information that the endocytosis efficiency of spherocylindrical bioparticles is decided by its aspect ratio. At the same time, the dimensions of the receptor-ligand complex have strong effects on the size-dependent exclusion of proteins within the cellular environment. However, these earlier theoretical works including simulations did not consider the effects of ligand-receptor complex dimension on the endocytosis process. Thus, it is necessary to resolve the effects of ligand-receptor complex dimension and determine the optimal aspect ratio of spherocylindrical bioparticles in the process of endocytosis. Accordingly, we proposed a continuum elastic model, of which the results indicate that the aspect ratio depends on the ligand-receptor complex dimension and the radius of the spherocylindrical bioparticle. This model provides a phase diagram of the aspect ratio of endocytosed spherocylindrical bioparticles, the larger aspect ratio of which appears in the phase diagram with increasing ligand density, and highlights the bioparticle design.
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Keywords
cellular uptake
depletion effects
dimension of ligand-receptor complex
elasticity theory
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Corresponding Author(s):
Hou-Qiang Xu
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Issue Date: 10 February 2015
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1 |
A. E. Nel, L. M?dler, D. Velegol, T. Xia, E. M. Hoek, P. Somasundaran, F. Klaessig, V. Castranova, and M. Thompson, Understanding biophysicochemical interactions at the nano-bio interface, Nat. Mater., 2009, 8(7): 543
https://doi.org/10.1038/nmat2442
|
2 |
M. Lakadamyali, M. J. Rust, and X. W. Zhuang, Endocytosis of influenza viruses, Microbes Infect., 1996, 6: 334
|
3 |
R. Vácha, F. J. Martinez-Veracoechea, and D. Frenkel, Receptor-mediated endocytosis of nanoparticles of various shapes, Nano Lett., 2011, 11 (12): 5391
https://doi.org/10.1021/nl2030213
|
4 |
C. J. Huang, Y. Zhang, H. Y. Yuan, H. J. Gao, and S. L. Zhang, Role of nanoparticle geometry in endocytosis: Laying down to stand up, Nano Lett., 2013, 13 (9): 4546
https://doi.org/10.1021/nl402628n
|
5 |
B. D. Chithrani, A. A. Ghazani, and W. C. Chan, Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells, Nano Lett., 2006, 6(4): 662
https://doi.org/10.1021/nl052396o
|
6 |
B. D. Chithrani and W. C. Chan, Elucidating the mechanism of cellular uptake and removal of protein-coated gold nanoparticles of different sizes and shapes, Nano Lett., 2007, 7(6): 1542
https://doi.org/10.1021/nl070363y
|
7 |
S. X. Sun and D. Wirtz, Mechanics of enveloped virus entry into host cells, Biophys. J., 2006, 90(1): L10
https://doi.org/10.1529/biophysj.105.074203
|
8 |
H. Gao, W. Shi, and L. B. Freund, Mechanics of receptormediated endocytosis, Proc. Natl. Acad. Sci. USA, 2005, 102(27): 9469
https://doi.org/10.1073/pnas.0503879102
|
9 |
J. Matti, Alakoskela, A. L. Koner, D. Rudnicka, , Mechanisms for size dependent protein segregation at immune synapses assessed with molecular rulers, Biophys. J., 2011, 100: 2865
https://doi.org/10.1016/j.bpj.2011.05.013
|
10 |
Y.-H. Liu, Y.-B. Chen, W. Mao, L. Hu, L.-H. Deng, and H.-Q. Xu, Dimensions of receptor-ligand complex and the optimal radius of endocytosed virus-like particle, Front. Phys., 2014, 9(4): 519
https://doi.org/10.1007/s11467-014-0412-6
|
11 |
S. Asakura and O. Osawa, On interaction between two bodies immersed in a solution of macromolecules, J. Chem. Phys., 1954, 22: 1255
https://doi.org/10.1063/1.1740347
|
12 |
N. Philip, Biological Physics: Energy, Information and Life, New York and Basingstoke: W. H. Freeman, 2007
|
13 |
Z.-C. Ou-Yang, J. X. Liu, and Y. Z. Xie, Geometric Methods in the Elastic Theory of Membranes in Liquid Crystal Phase, Singapore: World Scientific, 1999
https://doi.org/10.1142/9789812816856
|
14 |
L. D. Landau and E. M. Lifshitz, Theory of Elasticity, Oxford: Pergamon, 1986
|
15 |
G. I. Bell, Models for the specific adhesion of cells to cells, Science, 1978, 200: 618
https://doi.org/10.1126/science.347575
|
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