Mutation analysis of large tumor suppressor genes <i>LATS1</i> and <i>LATS2</i> supports a tumor suppressor role in human cancer

doi:10.1007/s13238-014-0122-4

Protein Cell

2015, Vol. 6

Issue (1) : 6-11 https://doi.org/10.1007/s13238-014-0122-4

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Mutation analysis of large tumor suppressor genes LATS1 and LATS2 supports a tumor suppressor role in human cancer

Tian Yu¹,John Bachman²,Zhi-Chun Lai^1,^2,^3,^*(

)

1. Intercollege Graduate Degree Program in Molecular, Cellular and Integrative Biosciences, The Pennsylvania State University, University Park, PA 16802, USA
2. Department of Biology, The Pennsylvania State University, University Park, PA 16802, USA
3. Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA

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Abstract

In recent years, human cancer genome projects provide unprecedented opportunities for the discovery of cancer genes and signaling pathways that contribute to tumor development. While numerous gene mutations can be identified from each cancer genome, what these mutations mean for cancer is a challenging question to address, especially for those from less understood putative new cancer genes. As a powerful approach, in silico bioinformatics analysis could efficiently sort out mutations that are predicted to damage gene function. Such an analysis of human large tumor suppressor genes, LATS1 and LATS2, has been carried out and the results support a role of hLATS1//2 as negative growth regulators and tumor suppressors.

Keywords LATS1 & LATS2 hippo signaling cancer genome human cancer

Corresponding Author(s): Zhi-Chun Lai

Issue Date: 22 January 2015

Cite this article:

Tian Yu,John Bachman,Zhi-Chun Lai. Mutation analysis of large tumor suppressor genes LATS1 and LATS2 supports a tumor suppressor role in human cancer[J]. Protein Cell, 2015, 6(1): 6-11.

URL:

https://academic.hep.com.cn/pac/EN/10.1007/s13238-014-0122-4
https://academic.hep.com.cn/pac/EN/Y2015/V6/I1/6

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