Structure of unliganded membrane-proximal domains FN4-FN5-FN6 of DCC

doi:10.1007/s13238-017-0439-x

Protein Cell

2017, Vol. 8

Issue (9) : 701-705 https://doi.org/10.1007/s13238-017-0439-x

LETTER

Structure of unliganded membrane-proximal domains FN4-FN5-FN6 of DCC

Lorenzo I. Finci^1,^2,⁶, Jie Zhang^1,⁷, Xiaqin Sun¹, Robert G. Smock³, Rob Meijers³, Yan Zhang^1,⁴(

), Junyu Xiao⁵, Jia-huai Wang^1,²(

)

¹. State Key Laboratory of Biomembrane and Membrane Biotechnology, College of Life Sciences, Peking University, Beijing 100871, China
². Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA
³. European Molecular Biology Laboratory (EMBL), Hamburg Outstation, Hamburg, Germany
⁴. PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing 100871, China
⁵. State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, and Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China
⁶. Present address Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Center for Life Sciences, School of Life Sciences and School of Medicine, Tsinghua University, Beijing 100084, China
⁷. The Francis Crick Institute, London NW1 2BE, UK

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Corresponding Author(s): Yan Zhang,Jia-huai Wang

Issue Date: 20 September 2017

Cite this article:

Lorenzo I. Finci,Jie Zhang,Xiaqin Sun, et al. Structure of unliganded membrane-proximal domains FN4-FN5-FN6 of DCC[J]. Protein Cell, 2017, 8(9): 701-705.

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https://academic.hep.com.cn/pac/EN/10.1007/s13238-017-0439-x
https://academic.hep.com.cn/pac/EN/Y2017/V8/I9/701

1	AhmedG, ShinmyoY, OhtaK, IslamSM, HossainM, NaserIB, RiyadhMA, SuY, ZhangS, Tessier-LavigneMet al. (2011) Draxin inhibits axonal outgrowth through the netrin receptor DCC.J Neurosci31:14018–14023 https://doi.org/10.1523/JNEUROSCI.0943-11.2011
2	BushellKM, SollnerC, Schuster-BoecklerB, BatemanA, WrightGJ (2008) Large-scale screening for novel low-affinity extracellular protein interactions.Genome Res18:622–630 https://doi.org/10.1101/gr.7187808
3	CooperHM, ArmesP, BrittoJ, GadJ, WilksAF (1995) Cloning of the mouse homologue of the deleted in colorectal cancer gene (mDCC) and its expression in the developing mouse embryo.Oncogene11:2243–2254
4	FearonER, ChoKR, NigroJM, KernSE, SimonsJW, RuppertJM, HamiltonSR, PreisingerAC, ThomasG, KinzlerKWet al. (1990) Identification of a chromosome 18q gene that is altered in colorectal cancers.Science247:49–56 https://doi.org/10.1126/science.2294591
5	FinciLI, KrugerN, SunX, ZhangJ, ChegkaziM, WuY, SchenkG, MertensHD, SvergunDI, ZhangYet al. (2014) The crystal structure of netrin-1 in complex with DCC reveals the bifunctionality of netrin-1 as a guidance cue.Neuron83:839–849 https://doi.org/10.1016/j.neuron.2014.07.010
6	FinciL, ZhangY, MeijersR, WangJ-H (2015) Signaling mechanism of the netrin-1 receptor DCC in axon guidance.Prog Biophys Mol Biol118:153–160 https://doi.org/10.1016/j.pbiomolbio.2015.04.001
7	GaoX, MetzgerU, PanzaP, MahalwarP, AlsheimerS, GeigerH, MaischeinHM, LevesqueMP, TemplinM, SollnerC (2015) A floor-plate extracellular protein-protein interaction screen identifies draxin as a secreted netrin-1 antagonist.Cell Rep12:694–708 https://doi.org/10.1016/j.celrep.2015.06.047
8	HongK, HinckL, NishiyamaM, PooMM, Tessier-LavigneM, SteinE (1999) A ligand-gated association between cytoplasmic domains of UNC5 and DCC family receptors converts netrin-induced growth cone attraction to repulsion.Cell97:927–941 https://doi.org/10.1016/S0092-8674(00)80804-1
9	JaninJ (1997) Specific versus non-specific contacts in protein crystals.Nat Struct Biol4:973–974 https://doi.org/10.1038/nsb1297-973
10	KennedyTE, SerafiniT, de la TorreJR, Tessier-LavigneM (1994) Netrins are diffusible chemotropic factors for commissural axons in the embryonic spinal cord.Cell78:425–435 https://doi.org/10.1016/0092-8674(94)90421-9
11	LeggereJC, SaitoY, DarnellRB, Tessier-LavigneM, JungeHJ, ChenZ (2016) NOVA regulates Dcc alternative splicing during neuronal migration and axon guidance in the spinal cord.eLife 5, e14264 https://doi.org/10.7554/eLife.14264
12	RounsevellRW, ClarkeJ (2004) FnIII domains: predicting mechanical stability.Structure12:4–5 https://doi.org/10.1016/j.str.2003.12.006
13	VakonakisI, StauntonD, RooneyLM, CampbellID (2007) Interdomain association in fibronectin: insight into cryptic sites and fibrillogenesis.EMBO J26:2575–2583 https://doi.org/10.1038/sj.emboj.7601694
14	XuK, WuZ, RenierN, AntipenkoA, Tzvetkova-RobevD, XuY, MinchenkoM, Nardi-DeiV, RajashankarKR, HimanenJet al. (2014) Neural migration. Structures of netrin-1 bound to two receptors provide insight into its axon guidance mechanism.Science344:1275–1279 https://doi.org/10.1126/science.1255149

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