Single senescent cell sequencing reveals heterogeneity in senescent cells induced by telomere erosion

doi:10.1007/s13238-018-0591-y

Protein Cell

2019, Vol. 10

Issue (5) : 370-375 https://doi.org/10.1007/s13238-018-0591-y

LETTER

Single senescent cell sequencing reveals heterogeneity in senescent cells induced by telomere erosion

Huanyin Tang¹, Anke Geng¹, Tengjiao Zhang², Chen Wang², Ying Jiang¹, Zhiyong Mao¹(

)

¹. Clinical and Translational Research Center of Shanghai First Maternity Infant Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China
². School of Life Sciences and Technology, Tongji University, Shanghai 200092, China

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Corresponding Author(s): Zhiyong Mao

Issue Date: 14 May 2019

Cite this article:

Huanyin Tang,Anke Geng,Tengjiao Zhang, et al. Single senescent cell sequencing reveals heterogeneity in senescent cells induced by telomere erosion[J]. Protein Cell, 2019, 10(5): 370-375.

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https://academic.hep.com.cn/pac/EN/10.1007/s13238-018-0591-y
https://academic.hep.com.cn/pac/EN/Y2019/V10/I5/370

1	JCAcosta, ABanito, TWuestefeld, AGeorgilis, PJanich, JPMorton, DAthineos, TWKang, FLasitschka, MAndruliset al. (2013) A complex secretory program orchestrated by the inflammasome controls paracrine senescence. Nat Cell Biol 15:978–990 https://doi.org/10.1038/ncb2784
2	JCampisi (2013) Aging, cellular senescence, and cancer. Annu Rev Physiol 75:685–705 https://doi.org/10.1146/annurev-physiol-030212-183653
3	TChandra, PAEwels, SSchoenfelder, MFurlan-Magaril, SWWingett, KKirschner, JYThuret, SAndrews, PFraser, WTReik (2015) Global reorganization of the nuclear landscape in senescent cells. Cell Rep 10:471–483 https://doi.org/10.1016/j.celrep.2014.12.055
4	LHayflick, PSMoorhead (1961) The serial cultivation of human diploid cell strains. Exp Cell Res 25:585–621 https://doi.org/10.1016/0014-4827(61)90192-6
5	MHoare, YIto, TWKang, MPWeekes, NJMatheson, DAPatten, SShetty, AJParry, SMenon, RSalamaet al. (2016) NOTCH1 mediates a switch between two distinct secretomes during senescence. Nat Cell Biol 18:979–992 https://doi.org/10.1038/ncb3397
6	VKrizhanovsky, MYon, RADickins, SHearn, JSimon, CMiething, HYee, LZender, SWLowe (2008) Senescence of activated stellate cells limits liver fibrosis. Cell 134:657–667 https://doi.org/10.1016/j.cell.2008.06.049
7	DWLamming, LYe, DMSabatini, JABaur (2013) Rapalogs and mTOR inhibitors as anti-aging therapeutics. J Clin Investig 123:980–989 https://doi.org/10.1172/JCI64099
8	EZMacosko, ABasu, RSatija, JNemesh, KShekhar, MGoldman, ITirosh, ARBialas, NKamitaki, EMMarterstecket al. (2015) Highly parallel genome-wide expression profiling of individual cells using nanoliter droplets. Cell 161:1202–1214 https://doi.org/10.1016/j.cell.2015.05.002
9	ZMao, ZKe, VGorbunova, ASeluanov (2012) Replicatively senescent cells are arrested in G1 and G2 phases. Aging 4:431–435 https://doi.org/10.18632/aging.100467
10	DMunoz-Espin, MSerrano (2014) Cellular senescence: from physiology to pathology. Nat Rev Mol Cell Biol 15:482–496 https://doi.org/10.1038/nrm3823
11	SGRao, JGJackson (2016) SASP: tumor suppressor or promoter? Yes! Trends Cancer 2:676–687 https://doi.org/10.1016/j.trecan.2016.10.001
12	CDWiley, JMFlynn, CMorrissey, RLebofsky, JShuga, XDong, MAUnger, JVijg, SMelov, JCampisi (2017) Analysis of individual cells identifies cell-to-cell variability following induction of cellular senescence. Aging Cell 16:1043–1050 https://doi.org/10.1111/acel.12632
13	MXu, TPirtskhalava, JNFarr, BMWeigand, AKPalmer, MMWeivoda, CLInman, MBOgrodnik, CMHachfeld, DGFraseret al. (2018) Senolytics improve physical function and increase lifespan in old age. Nat Med 24:1246–1256 https://doi.org/10.1038/s41591-018-0092-9

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