|
|
|
Recapitulation of SARS-CoV-2 infection and cholangiocyte damage with human liver ductal organoids |
Bing Zhao1( ), Chao Ni1, Ran Gao2, Yuyan Wang3, Li Yang1, Jinsong Wei1, Ting Lv4, Jianqing Liang1, Qisheng Zhang5, Wei Xu3, Youhua Xie3, Xiaoyue Wang2, Zhenghong Yuan3, Junbo Liang2(), Rong Zhang3(), Xinhua Lin1() |
1. State Key Laboratory of Genetic Engineering, School of Life Sciences, Zhongshan Hospital, Fudan University, Shanghai 200438, China
2. State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100005, China
3. Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China
4. Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai 200040, China
5. Sino Organoid Lifesciences Ltd., Shanghai 201900, China |
|
|
|
|
|
|
Corresponding Author(s):
Bing Zhao,Junbo Liang,Rong Zhang,Xinhua Lin
|
|
Online First Date: 14 September 2020
Issue Date: 12 October 2020
|
|
| 1 |
X Chai, L Hu, Y Zhang, W Han, Z Lu, A Ke, J Zhou, G Shi, N Fang, J Fan, et al. (2020) Specific ACE2 expression in cholangiocytes may cause liver damage after 2019-nCoV infection. bioRxiv
https://doi.org/10.1101/2020.02.03.931766
|
| 2 |
N Chen, M Zhou, X Dong, J Qu, F Gong, Y Han, Y Qiu, J Wang, Y Liu, Y Weiet al. (2020) Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet 395:507–513
https://doi.org/10.1016/S0140-6736(20)30211-7
|
| 3 |
D Dutta, H Clevers (2017) Organoid culture systems to study hostpathogen interactions. Curr Opin Immunol 48:15–22
https://doi.org/10.1016/j.coi.2017.07.012
|
| 4 |
Z Fan, L Chen, J Li, C Tian, Y Zhang, S Huang, Z Liu, J Cheng (2020) Clinical features of COVID-19 related liver damage. medRxiv
https://doi.org/10.1101/2020.02.26.20026971
|
| 5 |
M Hoffmann, H Kleine-Weber, S Schroeder, N Kruger, T Herrler, S Erichsen, TS Schiergens, G Herrler, NH Wu, A Nitsche, et al. (2020) SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell
https://doi.org/10.1016/j.cell.2020.02.052
|
| 6 |
C Huang, Y Wang, X Li, L Ren, J Zhao, Y Hu, L Zhang, G Fan, J Xu, X Guet al. (2020) Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 395:497–506
https://doi.org/10.1016/S0140-6736(20)30183-5
|
| 7 |
M Huch, H Gehart, R van Boxtel, K Hamer, F Blokzijl, MM Verstegen, E Ellis, M van Wenum, SA Fuchs, J de Ligtet al. (2015) Long-term culture of genome-stable bipotent stem cells from adult human liver. Cell 160:299–312
https://doi.org/10.1016/j.cell.2014.11.050
|
| 8 |
JH Kuhn, W Li, H Choe, M Farzan (2004) Angiotensin-converting enzyme 2: a functional receptor for SARS coronavirus. Cell Mol Life Sci 61:2738–2743
https://doi.org/10.1007/s00018-004-4242-5
|
| 9 |
F Qi, S Qian, S Zhang, Z Zhang (2020) Single cell RNA sequencing of 13 human tissues identify cell types and receptors of human coronaviruses. bioRxiv
https://doi.org/10.1101/2020.02.16.951913
|
| 10 |
, Y. Wan, , J. Shang, , R. Graham, , R.S. Baric, and , F. Li (2020). Receptor Recognition by the Novel Coronavirus from Wuhan: an Analysis Based on Decade-Long Structural Studies of SARS Coronavirus. J Virol94.
https://doi.org/10.1128/JVI.00127-20
|
| 11 |
F Wu, S Zhao, B Yu, YM Chen, W Wang, ZG Song, Y Hu, ZW Tao, JH Tian, YY Peiet al. (2020) A new coronavirus associated with human respiratory disease in China. Nature 579:265–269
https://doi.org/10.1038/s41586-020-2008-3
|
| 12 |
Z Xu, L Shi, Y Wang, J Zhang, L Huang, C Zhang, S Liu, P Zhao, H Liu, L Zhu, et al. (2020) Pathological findings of COVID-19 associated with acute respiratory distress syndrome. Lancet Respir Med
https://doi.org/10.1016/S2213-2600(20)30076-X
|
| 13 |
H Zhang, Z Kang, H Gong, D Xu, J Wang, Z Li, X Cui, J Xiao, T Meng, W Zhou, et al. (2020) The digestive system is a potential route of 2019-nCov infection: a bioinformatics analysis based on single-cell transcriptomes. bioRxiv
https://doi.org/10.1101/2020.01.30.927806
|
| 14 |
, Y. Zhao, , Z. Zhao, , Y. Wang, , Y. Zhou, , Y. Ma, and , W. Zuo (2020). Single-cell RNA expression profiling of ACE2, the putative receptor of Wuhan 2019-nCov. bioRxiv.
https://doi.org/10.1101/2020.01.26.919985
|
| 15 |
N Zhu, D Zhang, W Wang, X Li, B Yang, J Song, X Zhao, B Huang, W Shi, R Luet al. (2020) A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med 382:727–733
https://doi.org/10.1056/NEJMoa2001017
|
|
Viewed |
|
|
|
Full text
|
|
|
|
|
Abstract
|
|
|
|
|
Cited |
|
|
|
|
| |
Shared |
|
|
|
|
| |
Discussed |
|
|
|
|
