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Protein Cell    2022, Vol. 13 Issue (1) : 6-25    https://doi.org/10.1007/s13238-020-00812-9
REVIEW
The p21-activated kinases in neural cytoskeletal remodeling and related neurological disorders
Kaifan Zhang1,2, Yan Wang1(), Tianda Fan2, Cheng Zeng1,3, Zhong Sheng Sun1,2,3,4()
1. Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing 100101, China
2. Institute of Genomic Medicine, Wenzhou Medical University, Wenzhou 325000, China
3. CAS Center for Excellence in Biotic Interactions, University of Chinese Academy of Sciences, Beijing 100049, China
4. State Key Laboratory of Integrated Management of Pest Insects and Rodents, Chinese Academy of Sciences, Beijing 100101, China
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Abstract

The serine/threonine p21-activated kinases (PAKs), as main effectors of the Rho GTPases Cdc42 and Rac, represent a group of important molecular switches linking the complex cytoskeletal networks to broad neural activity. PAKs show wide expression in the brain, but they differ in specific cell types, brain regions, and developmental stages. PAKs play an essential and differential role in controlling neural cytoskeletal remodeling and are related to the development and fate of neurons as well as the structural and functional plasticity of dendritic spines. PAK-mediated actin signaling and interacting functional networks represent a common pathway frequently affected in multiple neurodevelopmental and neurodegenerative disorders. Considering specific small-molecule agonists and inhibitors for PAKs have been developed in cancer treatment, comprehensive knowledge about the role of PAKs in neural cytoskeletal remodeling will promote our understanding of the complex mechanisms underlying neurological diseases, which may also represent potential therapeutic targets of these diseases.
Keywords p21-activated kinases      expression pattern      synaptic cytoskeletal remodeling      neuronal function      neurological diseases     
Corresponding Author(s): Yan Wang,Zhong Sheng Sun   
Online First Date: 11 January 2021    Issue Date: 14 February 2022
 Cite this article:   
Kaifan Zhang,Yan Wang,Tianda Fan, et al. The p21-activated kinases in neural cytoskeletal remodeling and related neurological disorders[J]. Protein Cell, 2022, 13(1): 6-25.
 URL:  
https://academic.hep.com.cn/pac/EN/10.1007/s13238-020-00812-9
https://academic.hep.com.cn/pac/EN/Y2022/V13/I1/6
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