Recent progress and challenges in the treatment of spinal cord injury

doi:10.1093/procel/pwad003

Protein Cell

2023, Vol. 14

Issue (9) : 635-652 https://doi.org/10.1093/procel/pwad003

REVIEW

Recent progress and challenges in the treatment of spinal cord injury

Ting Tian¹, Sensen Zhang¹, Maojun Yang^1,²(

)

¹. Ministry of Education Key Laboratory of Protein Science, Beijing Advanced Innovation Center for Structural Biology, Beijing Frontier Research Center for Biological Structure, School of Life Sciences, Tsinghua University, Beijing 100084, China
². Cryo-EM Facility Center, Southern University of Science and Technology, Shenzhen 518055, China

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Abstract

Spinal cord injury (SCI) disrupts the structural and functional connectivity between the higher center and the spinal cord, resulting in severe motor, sensory, and autonomic dysfunction with a variety of complications. The pathophysiology of SCI is complicated and multifaceted, and thus individual treatments acting on a specific aspect or process are inadequate to elicit neuronal regeneration and functional recovery after SCI. Combinatory strategies targeting multiple aspects of SCI pathology have achieved greater beneficial effects than individual therapy alone. Although many problems and challenges remain, the encouraging outcomes that have been achieved in preclinical models offer a promising foothold for the development of novel clinical strategies to treat SCI. In this review, we characterize the mechanisms underlying axon regeneration of adult neurons and summarize recent advances in facilitating functional recovery following SCI at both the acute and chronic stages. In addition, we analyze the current status, remaining problems, and realistic challenges towards clinical translation. Finally, we consider the future of SCI treatment and provide insights into how to narrow the translational gap that currently exists between preclinical studies and clinical practice. Going forward, clinical trials should emphasize multidisciplinary conversation and cooperation to identify optimal combinatorial approaches to maximize therapeutic benefit in humans with SCI.

Keywords spinal cord injury axon regeneration functional recovery therapeutic strategies clinical translation

Corresponding Author(s): Maojun Yang

Issue Date: 12 October 2023

Cite this article:

Ting Tian,Sensen Zhang,Maojun Yang. Recent progress and challenges in the treatment of spinal cord injury[J]. Protein Cell, 2023, 14(9): 635-652.

URL:

https://academic.hep.com.cn/pac/EN/10.1093/procel/pwad003
https://academic.hep.com.cn/pac/EN/Y2023/V14/I9/635

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Dandan Luo, Weihong Ge, Xiao Hu, Chen Li, Chia-Ming Lee, Liqiang Zhou, Zhourui Wu, Juehua Yu, Sheng Lin, Jing Yu, Wei Xu, Lei Chen, Chong Zhang, Kun Jiang, Xingfei Zhu, Haotian Li, Xinpei Gao, Yanan Geng, Bo Jing, Zhen Wang, Changhong Zheng, Rongrong Zhu, Qiao Yan, Quan Lin, Keqiang Ye, Yi E. Sun, Liming Cheng. Unbiased transcriptomic analyses reveal distinct effects of immune deficiency in CNS function with and without injury[J]. Protein Cell, 2019, 10(8): 566-582.

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