转化医学研究
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2011年, 第1卷 第2期 出版日期:2011-02-20

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专论
转化医学在协和:过去、现在与未来
赵玉沛
转化医学研究. 2011, 1 (2): 1-7.  

摘要   PDF (2349KB)
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Tiantan stroke clinical and translational research in practice: advancing from theory
Yi-long Wang,Yong-jun Wang*
转化医学研究. 2011, 1 (2): 8-16.  

摘要   PDF (4092KB)
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天坛医院脑血管病转化医学研究实践---走出概念
王伊龙王拥军
转化医学研究. 2011, 1 (2): 8-16.  

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综述
Biopharmaceutical quality control and translational medicine
Kai Gao,Jun-zhi Wang*
转化医学研究. 2011, 1 (2): 17-28.  

摘要   PDF (5279KB)
Translational medicine aims to promote the rapid translation of basic research discoveries into the diagnosis, prevention, and treatment of diseases. The core idea of translational medicine is to create a two-way channel between basic research and clinical practice. Biopharmaceuticals are an important achievement in health research and one of the most promising industries of the 21st century, and are therefore creating new opportunities for prevention and treatment of human diseases. Research on the quality control and standardization of biopharmaceuticals is a key element of translational medicine and also a critical measure to ensure the efficacy, safety and quality control of biopharmaceuticals.
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生物技术药物质量控制与转化医学
高凯王军志
转化医学研究. 2011, 1 (2): 17-28.  

摘要   PDF (4114KB)
转化医学旨在推动基础研究成果快速临床转化并用于疾病诊断、预防和治疗, 其核心理念是在基础研究和临床实践之间建立一个双向转化通道。生物技术药物作为医药领域研究的重要成果和本世纪最具发展潜力的高新技术产业, 已为人类的疾病防治带来更多的手段。在生物药物产业化进程中, 质量控制与标准化研究作为转化医学的一部分, 是确保其安全有效、质量可控的重要保障。
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转化医学在眼科的应用
张敬学王宁利
转化医学研究. 2011, 1 (2): 29-43.  

摘要   PDF (5881KB)
与其他学科类似, 眼科仍有很多疾病尚无有效治疗方法, 需要前沿技术的转化应用。近年来, 转化医学在眼科应用取得了很大成绩, 为其他学科提供了较好的范例, 如抗VEGF药物对新生血管的治疗研究、干细胞移植及神经营养因子对退行性致盲眼病的治疗研究、Leber先天性黑矇的基因治疗研究以及人工视觉研究等。
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The application of translational medicine in ophthalmology
Jing-xue Zhang,Ning-li Wang*
转化医学研究. 2011, 1 (2): 29-43.  

摘要   PDF (7374KB)
Similar to other disciplines, there are many diseases have no effective treatment in ophthalmology, so we need promote the clinical applications of basic scientific research. Recently, many translational researches in ophthalmology have gained great achievement, and provided great examples for other subjects, including studies on treatment of angiogenesis by anti-VEGF drugs and degenerative blinding diseases by stem cell and neurotrophic factors, study on gene therapy of Leber congenital amaurosis and artificial vision research, etc.
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Biobank and translational medicine
Lei Zhang,Hai-yan Li,Ke-fang Fan,Xiu-li Han,Chun-yan Hu,Xiao-min Wang
转化医学研究. 2011, 1 (2): 44-55.  

摘要   PDF (5044KB)
Biobanks are unified resources that include bio specimens, phenotype data, molecular information generated from the specimens. It plays an irreplaceable role in the studies of human disease prediction, diagnosis and treatment. The emergence and development of the translational medicine has posed an increasing requirement to the bio samples resources. Biobanks are evolving from single centered to multi centered and national scale. As the foundation to the translational medicine, biobanks need to be improved, so to fulfill the bio sample types, contents, sample scales, sample standardization, quality control, ethic protection and resource sharing requirements posed by the translational medicine.
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生物样本库与转化医学研究
张雷,李海燕,范可方,韩秀丽,胡纯严,王晓民
转化医学研究. 2011, 1 (2): 44-55.  

摘要   PDF (4477KB)
生物样本库是融合生物样本实体、生物分子信息以及样本表型数据的综合资源, 对于开展人类疾病预测、诊断、治疗研究具有不可替代的重要作用。转化医学的兴起和发展对生物样本资源的迫切需求与日俱增, 生物样本库从传统的单中心模式跃升到多中心网络化和国家级统筹发展的层次。作为支撑转化医学的重要基石, 生物样本库需要进一步改进和完善, 在生物样本类型、内容构成、样本规模、标准规范、质量控制、伦理保护、资源共享等方面满足转化医学的需求。
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Translational research advances in cancer therapy
Yong-sheng Wang,Zhen-yu Ding,Yu-quan Wei*
转化医学研究. 2011, 1 (2): 56-65.  

摘要   PDF (4068KB)
Biotherapy is the fourth modality of cancer therapy and the important field of medical translational researches. Cancer biotherapies, including tumor vaccines, gene therapy, anti-angiogenic therapy, targeted therapy, and etc have made great progress in clinical translational research in recent years. Simultaneously, the new challenges that clinical investigations of cancer biotherapy have brought to translational researches will be discussed in the mini review.
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肿瘤生物治疗转化研究进展
王永生丁振宇魏于全
转化医学研究. 2011, 1 (2): 56-65.  

摘要   PDF (4039KB)
肿瘤生物治疗是继手术、放疗、化疗后的第四大治疗手段, 也是医学转化研究的热点。近年来, 肿瘤疫苗、基因治疗、抗血管生成治疗、靶向治疗向等在临床转化研究方面取得了较大进展, 同时, 生物治疗的临床研究也对转化研究提出了新的挑战。
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观点与视角
中国转化医学的侧重点与思考
王小宁
转化医学研究. 2011, 1 (2): 66-77.  

摘要   PDF (4858KB)
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Priority addressed for the translational medicine in China
Xiao-ning Wang*
转化医学研究. 2011, 1 (2): 66-77.  

摘要   PDF (6863KB)
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