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Frontiers of Medicine

ISSN 2095-0217

ISSN 2095-0225(Online)

CN 11-5983/R

Postal Subscription Code 80-967

2018 Impact Factor: 1.847

Front Med    2013, Vol. 7 Issue (3) : 389-394     DOI: 10.1007/s11684-013-0281-3
COMMENTARY |
Cultural differences define diagnosis and genomic medicine practice: implications for undiagnosed diseases program in China
Xiaohong Duan1(), Thomas Markello2, David Adams2, Camilo Toro2, Cynthia Tifft2, William A. Gahl2, Cornelius F. Boerkoel2
1. Department of Oral Biology, Clinic of Oral Rare Diseases and Genetic Diseases, School of Stomatology, the Fourth Military Medical University, Xi’an 710032, China; 2. NIH Undiagnosed Diseases Program, NIH Office of Rare Diseases Research and NHGRI, Bethesda, MD, USA
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Abstract  

Despite the current acceleration and increasing leadership of Chinese genetics research, genetics and its clinical application have largely been imported to China from the Occident. Neither genetics nor the scientific reductionism underpinning its clinical application is integral to the traditional Chinese worldview. Given that disease concepts and their incumbent diagnoses are historically derived and culturally meaningful, we hypothesize that the cultural expectations of genetic diagnoses and medical genetics practice differ between the Occident and China. Specifically, we suggest that an undiagnosed diseases program in China will differ from the recently established Undiagnosed Diseases Program at the United States National Institutes of Health; a culturally sensitive concept will integrate traditional Chinese understanding of disease with the scientific reductionism of Occidental medicine.

Keywords genetics      cultural differences      undiagnosed diseases program     
Corresponding Authors: Duan Xiaohong,Email:xhduan@fmmu.edu.cn   
Issue Date: 05 September 2013
URL:  
http://academic.hep.com.cn/fmd/EN/10.1007/s11684-013-0281-3     OR     http://academic.hep.com.cn/fmd/EN/Y2013/V7/I3/389
Fig.1  Annual number of articles from Chinese institutions that were published in the ten journals with the highest 5-year impact factors in the discipline of genetics and heredity (2011 JCR data).
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