LETTER TO FRONTIERS OF MEDICINE |
|
|
|
White blood cell count and the incidence of hyperuricemia: insights from a community-based study |
Jian Liu, Pingyan Shen, Xiaobo Ma, Xialian Yu, Liyan Ni, Xu Hao, Weiming Wang(), Nan Chen |
Department of Nephrology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; Institute of Nephrology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China |
|
|
Abstract Hyperuricemia (HUA) is a risk factor for chronic kidney disease (CKD). The relationship between HUA and white blood cell (WBC) count remains unknown. A sampling survey for CKD was conducted in Sanlin community in 2012 and 2014. CKD was defined as proteinuria in at least the microalbuminuric stage or an estimated GFR of 60 mL/(min·1.73 m2). HUA was defined as serum uric acid>420 µmol/L in men and>360 µmol/L in women. This study included 1024 participants. The prevalence of HUA was 17.77%. Patients with HUA were more likely to have higher levels of WBC count, which was positively associated with HUA prevalence. This association was also observed in participants without CKD, diabetes mellitus, hyperlipidemia, or obesity. Multivariate logistic regression analysis showed that WBC count was independently associated with the risk for HUA in male and female participants. Compared with participants without HUA, inflammatory factors such as high-sensitivity C-reactive protein, tumor necrosis factor-α, and interleukin 6 increased in participants with HUA. Hence, WBC count is positively associated with HUA, and this association is independent of conventional risk factors for CKD.
|
Keywords
white blood cell count
hyperuricemia
chronic kidney disease
inflammation
|
Corresponding Author(s):
Weiming Wang
|
Just Accepted Date: 27 December 2017
Online First Date: 25 June 2018
Issue Date: 16 December 2019
|
|
1 |
N Chen, W Wang, Y Huang, P Shen, D Pei, H Yu, H Shi, Q Zhang, J Xu, Y Lv, Q Fan. Community-based study on CKD subjects and the associated risk factors. Nephrol Dial Transplant 2009; 24(7): 2117–2123
https://doi.org/10.1093/ndt/gfn767
pmid: 19193736
|
2 |
L Zhang, F Wang, L Wang, W Wang, B Liu, J Liu, M Chen, Q He, Y Liao, X Yu, N Chen, JE Zhang, Z Hu, F Liu, D Hong, L Ma, H Liu, X Zhou, J Chen, L Pan, W Chen, W Wang, X Li, H Wang. Prevalence of chronic kidney disease in China: a cross-sectional survey. Lancet 2012; 379(9818): 815–822
https://doi.org/10.1016/S0140-6736(12)60033-6
pmid: 22386035
|
3 |
DI Jalal, M Chonchol, W Chen, G Targher. Uric acid as a target of therapy in CKD. Am J Kidney Dis 2013; 61(1): 134–146
https://doi.org/10.1053/j.ajkd.2012.07.021
pmid: 23058478
|
4 |
NF Chu, DJ Wang, SH Liou, SM Shieh. Relationship between hyperuricemia and other cardiovascular disease risk factors among adult males in Taiwan. Eur J Epidemiol 2000; 16(1): 13–17
https://doi.org/10.1023/A:1007654507054
pmid: 10780337
|
5 |
HJ Han, MJ Lim, YJ Lee, JH Lee, IS Yang, M Taub. Uric acid inhibits renal proximal tubule cell proliferation via at least two signaling pathways involving PKC, MAPK, cPLA2, and NF-κB. Am J Physiol Renal Physiol 2007; 292(1): F373–F381
https://doi.org/10.1152/ajprenal.00104.2006
pmid: 16985215
|
6 |
CA Roncal, W Mu, B Croker, S Reungjui, X Ouyang, I Tabah-Fisch, RJ Johnson, AA Ejaz. Effect of elevated serum uric acid on cisplatin-induced acute renal failure. Am J Physiol Renal Physiol 2007; 292(1): F116–F122
https://doi.org/10.1152/ajprenal.00160.2006
pmid: 17210794
|
7 |
DH Kang, T Nakagawa, L Feng, S Watanabe, L Han, M Mazzali, L Truong, R Harris, RJ Johnson. A role for uric acid in the progression of renal disease. J Am Soc Nephrol 2002; 13(12): 2888–2897
https://doi.org/10.1097/01.ASN.0000034910.58454.FD
pmid: 12444207
|
8 |
M Gür, DY Sahin, Z Elbasan, GY Kalkan, A Yıldız, Z Kaya, B Özaltun, M Çaylı. Uric acid and high sensitive C-reactive protein are associated with subclinical thoracic aortic atherosclerosis. J Cardiol 2013; 61(2): 144–148
https://doi.org/10.1016/j.jjcc.2012.08.023
pmid: 23159203
|
9 |
P Su, L Hong, Y Zhao, H Sun, L Li. Relationship between hyperuricemia and cardiovascular disease risk factors in a Chinese population: a cross-sectional study. Med Sci Monit 2015; 21: 2707–2717
https://doi.org/10.12659/MSM.895448
pmid: 26364955
|
10 |
YH Kang, HG Min, IJ Kim, YK Kim, SM Son. Comparison of alanine aminotransferase, white blood cell count, and uric acid in their association with metabolic syndrome: a study of Korean adults. Endocr J 2008; 55(6): 1093–1102
https://doi.org/10.1507/endocrj.K08E-077
pmid: 18753705
|
11 |
A Zhu, T Zou, G Xiong, J Zhang. Association of uric acid with traditional inflammatory factors in stroke. Int J Neurosci 2016; 126(4): 335–341
https://doi.org/10.3109/00207454.2015.1015723
pmid: 26001205
|
12 |
AS Levey, JP Bosch, JB Lewis, T Greene, N Rogers, D Roth. A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Ann Intern Med 1999; 130(6): 461–470
https://doi.org/10.7326/0003-4819-130-6-199903160-00002
pmid: 10075613
|
13 |
J Fang, MH Alderman. Serum uric acid and cardiovascular mortality. The NHANES I epidemiologic follow-up study, 1971–1992. JAMA 2000; 283(18): 2404–2410
https://doi.org/10.1001/jama.283.18.2404
pmid: 10815083
|
14 |
AV Chobanian, GL Bakris, HR Black, WC Cushman, LA Green, JL Izzo Jr, DW Jones, BJ Materson, S Oparil, JT Wright Jr, EJ Roccella; National Heart, Lung, and Blood Institute Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure; National High Blood Pressure Education Program Coordinating Committee. The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. JAMA 2003; 289(19): 2560–2572
https://doi.org/10.1001/jama.289.19.2560
pmid: 12748199
|
15 |
SA Kocaman, A Sahinarslan, M Cemri, T Timurkaynak, B Boyaci, A Cengel. Independent relationship of serum uric acid levels with leukocytes and coronary atherosclerotic burden. Nutr Metab Cardiovasc Dis 2009; 19(10): 729–735
https://doi.org/10.1016/j.numecd.2008.12.010
pmid: 19699626
|
16 |
P Su, L Hong, Y Zhao, H Sun, L Li. The association between hyperuricemia and hematological indicators in a Chinese adult population. Medicine (Baltimore) 2016; 95(7): e2822
https://doi.org/10.1097/MD.0000000000002822
pmid: 26886635
|
17 |
PF Li, JS Chen, JB Chang, HW Chang, CZ Wu, TJ Chuang, CL Huang, D Pei, CH Hsieh, YL Chen. Association of complete blood cell counts with metabolic syndrome in an elderly population. BMC Geriatr 2016; 16(1): 10
https://doi.org/10.1186/s12877-016-0182-9
pmid: 26758511
|
18 |
N Nakanishi, M Sato, K Shirai, K Nakajima, S Murakami, T Takatorige, K Suzuki, K Tatara. Associations between white blood cell count and features of the metabolic syndrome in Japanese male office workers. Ind Health 2002; 40(3): 273–277
https://doi.org/10.2486/indhealth.40.273
pmid: 12141376
|
19 |
YJ Lee, JW Lee, JK Kim, JH Lee, JH Kim, KY Kwon, HR Lee, DC Lee, JY Shim. Elevated white blood cell count is associated with arterial stiffness. Nutr Metab Cardiovasc Dis 2009; 19(1): 3–7
https://doi.org/10.1016/j.numecd.2008.02.003
pmid: 18456481
|
20 |
P Di Bonito, E Sanguigno, C Forziato, F Saitta, MR Iardino, B Capaldo. Fasting plasma glucose and clustering of cardiometabolic risk factors in normoglycemic outpatient children and adolescents. Diabetes Care 2011; 34(6): 1412–1414
https://doi.org/10.2337/dc10-1783
pmid: 21498784
|
21 |
N Nakanishi, H Yoshida, Y Matsuo, K Suzuki, K Tatara. White blood-cell count and the risk of impaired fasting glucose or Type II diabetes in middle-aged Japanese men. Diabetologia 2002; 45(1): 42–48
https://doi.org/10.1007/s125-002-8243-1
pmid: 11845222
|
22 |
RF Gillum, ME Mussolino. White blood cell count and hypertension incidence. The NHANES I Epidemiologic Follow-up Study. J Clin Epidemiol 1994; 47(8): 911–919
https://doi.org/10.1016/0895-4356(94)90195-3
pmid: 7730895
|
23 |
L Eder, A Thavaneswaran, V Chandran, R Cook, DD Gladman. Increased burden of inflammation over time is associated with the extent of atherosclerotic plaques in patients with psoriatic arthritis. Ann Rheum Dis 2015; 74(10): 1830–1835
https://doi.org/10.1136/annrheumdis-2014-205267
pmid: 24827532
|
24 |
BN Ames, R Cathcart, E Schwiers, P Hochstein. Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis. Proc Natl Acad Sci USA 1981; 78(11): 6858–6862
https://doi.org/10.1073/pnas.78.11.6858
pmid: 6947260
|
25 |
MG Netea, BJ Kullberg, WL Blok, RT Netea, JW van der Meer. The role of hyperuricemia in the increased cytokine production after lipopolysaccharide challenge in neutropenic mice. Blood 1997; 89(2): 577–582
pmid: 9002961
|
26 |
C Ruggiero, A Cherubini, A Ble, AJG Bos, M Maggio, VD Dixit, F Lauretani, S Bandinelli, U Senin, L Ferrucci. Uric acid and inflammatory markers. Eur Heart J 2006; 27(10): 1174–1181
https://doi.org/10.1093/eurheartj/ehi879
pmid: 16611671
|
|
Viewed |
|
|
|
Full text
|
|
|
|
|
Abstract
|
|
|
|
|
Cited |
|
|
|
|
|
Shared |
|
|
|
|
|
Discussed |
|
|
|
|