Although entrepreneurial orientation has been identified as a key facilitator of a firm’s innovative behaviors, its antecedents, especially the determinant role of the business leader, have yet to be explored. Drawing on strategic leadership theory, which posits the role of CEO in determining a firm’s strategic direction, we examined the influence of CEO demography, specifically age, tenure, and education, on a firm’s entrepreneurial orientation. Based on a sample of 231 Chinese firms, we found firms with a CEO who was younger, higher educated, and with a shorter tenure on the job had a greater extent of entrepreneurial orientation. Moreover, the firm’s competitive environment moderated these relationships.