A conjugated polymer - Gd (III) complex as pH sensitive contrast agent in magnetic resonance
imaging

doi:10.1007/s11458-010-0108-6

Front. Chem. China

2010, Vol. 5

Issue (2) : 166-170 https://doi.org/10.1007/s11458-010-0108-6

Research articles

A conjugated polymer - Gd (III) complex as pH sensitive contrast agent in magnetic resonance imaging

Qingling XU¹,Libing LIU¹,Minghui YU¹,Qiong YANG¹,Shu WANG¹,Litao ZHU²,

1.Beijing National Laboratory for Molecular Science, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China; 2.State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, China;

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Abstract A novel pH-responsive contrast agent (PFP-aa/Gd) for magnetic resonance imaging (MRI) was prepared by binding Gd(III) to a water-soluble conjugated polyfluorene with pendant carboxylate and amine moieties. The PFP-aa is a good chelator for Gd³⁺ and the PFP-aa/Gd complex has good stability. As the pH changes from 10.0 to 4.0, both the carboxylate and amine are protonated, thus PFP-aa exhibits positive charges and forms tight aggregation, which reduces molecular tumbling and accelerates the exchange of bound water leading to the increase of relaxivity R₁. More importantly, the R₁ increases by about eight fold as the pH changes from 8.0 to 6.0, which makes PFP-aa/Gd suitable as a potential marker of the pH below physiological level. In comparison to other contrast agents, the unique sensitivity of the water relaxivity of PFP-aa/Gd indicates that this complex could be used in MRI experiments to monitor physiological pH change.

Keywords magnetic resonance imaging pH-sensitive conjugated polymer Gd(III) chelate

Issue Date: 05 June 2010

Cite this article:

Qingling XU,Minghui YU,Libing LIU, et al. A conjugated polymer - Gd (III) complex as pH sensitive contrast agent in magnetic resonance imaging[J]. Front. Chem. China, 2010, 5(2): 166-170.

URL:

https://academic.hep.com.cn/fcc/EN/10.1007/s11458-010-0108-6
https://academic.hep.com.cn/fcc/EN/Y2010/V5/I2/166

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