The fast growing of urban areas in developing countries has brought serious problems on municipal solid waste (MSW) management. It will be rational to adopt an integrated approach to deal with such a challenge so that the overall eco-efficiency of MSW management could be improved. To better examine how attributes of integrated MSW management are being interpreted and put into practice, and to explore what changes should be made to improve the application of integrated MSW management, we employ a case study method so that lessons learned could be used to inform initiatives in other cities and the potential solution may offer feasible strategies. The case study city is Dalian, a typical seaport city with fast growing rate in economy. The outcomes of this case study show us that fragmented management structure, ineffective and inefficient enforcement of relevant regulations, backward technologies, limited financial resources and lack of public participation are main barriers for the implementation of integrated MSW management. Consequently, in order to overcome these barriers, we propose an integrated management framework on MSW management, aiming to maximize the overall eco-efficiency of MSW management.