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Epigenetic reprogramming: roads to pluripotency |
| Wei LI1,Qi ZHOU2, 3, |
| 1.State Key Laboratory
of Reproductive Biology, Institute of Zoology, Beijing 100101, China；Graduate School, Chinese
Academy of Sciences, Beijing 100049, China; 2.State Key Laboratory
of Reproductive Biology, Institute of Zoology, Beijing 100101, China; 3.2010-03-15 9:36:17; |
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Abstract Epigenetic reprogramming provides valuable resources for customized pluripotent stem cells generation, which are thought to be important bases of future regenerative medicine. Here we review the commonly used methods for epigenetic reprogramming: somatic cell nuclear transfer, cell fusion, cell extract treatment, inducing pluripotency by defined molecules, and briefly discuss their advantages and limitations. Finally we propose that mechanisms underlying epigenetic reprogramming and safety evaluation platform will be future research directions.
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| Keywords
Epigenetic reprogramming
pluripotency
regenerative medicine
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Issue Date: 01 February 2010
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