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Frontiers in Biology

ISSN 1674-7984

ISSN 1674-7992(Online)

CN 11-5892/Q

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Front Biol    2013, Vol. 8 Issue (1) : 101-108    https://doi.org/10.1007/s11515-012-1201-7
REVIEW
Exercise-dependent regulation of glial cell line-derived neurotrophic factor (GDNF) expression in skeletal muscle and its importance for the neuromuscular system
John-Mary VIANNEY, Monica J. MCCULLOUGH, Amy M. GYORKOS, John M. SPITSBERGEN()
Department of Biological Sciences, Western Michigan University, Kalamazoo, MI 49008-5410, USA
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Abstract

The focus of this review is to highlight the importance of glial cell line-derived neurotrophic factor (GDNF) for the motor nervous system. GDNF is the most potent survival factor for motor neurons, where it enhances maintenance and survival of both developing and mature motor neurons in vivo and in vitro. GDNF aids in neuromuscular junction formation, maintenance, and plasticity, where skeletal muscle-derived GDNF may be responsible for this phenomenon. Increased levels of physical activity can increase GDNF protein levels in skeletal muscle, where alterations in acetylcholine and acetylcholine receptor activation may be involved in regulation of these changes observed. With inactivity and disuse, GDNF expression shows different patterns of regulation in the central and peripheral nervous systems. Due to its potent effects for motor neurons, GDNF is being extensively studied in neuromuscular diseases.
Keywords glial cell line-derived neurotrophic factor      neuromuscular junction      motor neurons      skeletal muscle     
Corresponding Author(s): SPITSBERGEN John M.,Email:john.spitsbergen@wmich.edu   
Issue Date: 01 February 2013
 Cite this article:   
John-Mary VIANNEY,Monica J. MCCULLOUGH,Amy M. GYORKOS, et al. Exercise-dependent regulation of glial cell line-derived neurotrophic factor (GDNF) expression in skeletal muscle and its importance for the neuromuscular system[J]. Front Biol, 2013, 8(1): 101-108.
 URL:  
https://academic.hep.com.cn/fib/EN/10.1007/s11515-012-1201-7
https://academic.hep.com.cn/fib/EN/Y2013/V8/I1/101
FactorEffectSiteReferences
Walk training--EDLMcCullough et al., 2011, Wehrwein et al. 2002
+SOL
StretchnoneEDLMcCullough et al., 2011
+--SOL
Electrical stimulation--EDLMcCullough et al., 2011
+SOL
Hindlimb suspension--SOLWehrwein et al. 2002
+pectoralis major
Cholinergic neurons--skeletal muscle cells in cultureVianney and Spitsbergen, 2011
nAChR activation--skeletal muscle cells in cultureVianney and Spitsbergen, 2011
Spinal cord injury+skeletal muscleLie and Weis, 1998; Suzuki et al., 1988a; Trupp et al., 1995; Naveilhan et al., 1997
+spinal cordHashimoto et al., 2005
Spinal cord injury and exercise+SOLDupont-Versteegden et al., 2004
+spinal cordCote et al., 2011
Aging--skeletal muscleNagano and Suzuki, 2003
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