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Cytoplasmic dynein-2: from molecules to human diseases |
Vidyalakshmi RAJAGOPALAN, Jonathan P. D’AMICO, David E. WILKES( ) |
| Department of Biological Sciences, Indiana University South Bend, South Bend, IN 46634-7111, USA |
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Abstract The dynein motor protein family is involved in a wide variety of functions in eukaryotic cells. The axonemal dynein class and cytoplasmic dynein-1 subclass have been well characterized. However, the cytoplasmic dynein-2 subclass of the family has only recently begun to be understood. We describe the entire dynein family but focus on cytoplasmic dynein-2. Dynein-2 consists of a heavy, an intermediate, a light intermediate, and a light chain. The complex appears to function primarily as the retrograde motor for intraflagellar transport. This process is important for the formation and maintenance of cilia and flagella. Additionally, dynein-2 has roles in the control of ciliary length and in non-ciliary functions. Mutations in the human dynein-2 heavy chain lead to cilia-related diseases.
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| Keywords
cilia
dynein
flagella
intraflagellar transport
microtubule
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Corresponding Author(s):
WILKES David E.,Email:dewilkes@iusb.edu
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Issue Date: 01 February 2013
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