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Frontiers of Medicine

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Front. Med.    2020, Vol. 14 Issue (6) : 792-801    https://doi.org/10.1007/s11684-020-0745-1
RESEARCH ARTICLE
Cerebral regional and network characteristics in asthma patients: a resting-state fMRI study
Siyi Li1, Peilin Lv2, Min He3, Wenjing Zhang1, Jieke Liu4, Yao Gong5, Ting Wang3, Qiyong Gong1, Yulin Ji3(), Su Lui1()
1. Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu 610041, China
2. Department of Anesthesiology, West China Hospital of Sichuan University, Chengdu 610041, China
3. Department of Respiratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, China
4. Department of Radiology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610041, China
5. Department of Geriatric Psychiatry, The Fourth People’s Hospital of Chengdu, Chengdu 610036, China
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Abstract

Asthma is a serious health problem that involves not only the respiratory system but also the central nervous system. Previous studies identified either regional or network alterations in patients with asthma, but inconsistent results were obtained. A key question remains unclear: are the regional and neural network deficits related or are they two independent characteristics in asthma? Answering this question is the aim of this study. By collecting resting-state functional magnetic resonance imaging from 39 patients with asthma and 40 matched health controls, brain functional measures including regional activity (amplitude of low-frequency fluctuations) and neural network function (degree centrality (DC) and functional connectivity) were calculated to systematically characterize the functional alterations. Patients exhibited regional abnormities in the left angular gyrus, right precuneus, and inferior temporal gyrus within the default mode network. Network abnormalities involved both the sensorimotor network and visual network with key regions including the superior frontal gyrus and occipital lobes. Altered DC in the lingual gyrus was correlated with the degree of airway obstruction. This study elucidated different patterns of regional and network changes, thereby suggesting that the two parameters reflect different brain characteristics of asthma. These findings provide evidence for further understanding the potential cerebral alterations in the pathophysiology of asthma.
Keywords asthma      brain      regional activation      functional connectivity      resting-state fMRI     
Corresponding Author(s): Yulin Ji,Su Lui   
Just Accepted Date: 17 January 2020   Online First Date: 08 April 2020    Issue Date: 24 December 2020
 Cite this article:   
Siyi Li,Peilin Lv,Min He, et al. Cerebral regional and network characteristics in asthma patients: a resting-state fMRI study[J]. Front. Med., 2020, 14(6): 792-801.
 URL:  
https://academic.hep.com.cn/fmd/EN/10.1007/s11684-020-0745-1
https://academic.hep.com.cn/fmd/EN/Y2020/V14/I6/792
Asthma patients HCsa P
Mean SD Mean SD
Age (year) 34.54 9.05 33.9 8.01 0.54
Gender (male/female) 11/28 − 10/30 − 0.53
Education (year) 11.46 3.71 12.8 4.21 0.62
BMIb (kg/m2) 23.10 2.80 21.41 2.83 0.76
HRSDc score 7.62 6.84
HRSAd score 6.03 5.17
FEV1e (%) 2.28 0.57
FVCf (%) 3.12 0.57
FEV1/FVC (%) 71.88 13.58
Severity of illness score 2.29 1.06
Duration of illness (year) 5.88 8.05 　 　 　
Tab.1  Demographics and clinical characteristics of study participants
　 Brain areas x y z Voxels T P
ALFFa
Patients<HCsb Left angular gyrus −45 −69 30 149 3.93 <0.05
Right precuneus 3 −54 18 165 3.53 <0.05
Patients>HCs Right inferior temporal gyrus 54 −3 −33 105 3.18 <0.05
Degree centrality
Patients<HCs Left caudate −12 9 3 110 3.94 <0.05
Left lingual gyrus −15 −87 −18 472 4.07 <0.05
　 Right middle occipital gyrus 39 −72 12 398 3.92 <0.05
Tab.2  Amplitude of low-frequency fluctuation and degree centrality of significant brain areas with comparisons between patients with asthma and healthy controls
Fig.1  Patients with asthma showed decreased amplitude of low-frequency fluctuation (ALFF) values in the left angular gyrus and right precuneus (green and blue) and increased ALFF values in the right inferior temporal gyrus (red and yellow).
Fig.2  Patients with asthma showed decreased degree centrality in the left caudate, left lingual gyrus, and right middle occipital gyrus, extending to the right inferior occipital gyrus (green and blue).
Seed Connected area x y z Voxels T P
Left caudate Left superior frontal gyrus −9 −9 78 511 3.83 <0.05
Right inferior occipital gyrus 45 −78 −18 755 4.28 <0.05
Left lingual gyrus Left superior frontal gyrus −4 33 33 185 3.50 <0.05
Right middle occipital gyrus Left superior frontal gyrus −12 28 40 146 3.23 <0.05
Tab.3  Decreased functional connectivity of significant brain areas with comparisons between patients with asthma and healthy controls
Fig.3  Patients with asthma showed decreased functional connectivity between left caudate seed and left superior frontal gyrus and right inferior occipital gyrus; between left lingual gyrus seed and left superior frontal gyrus; and between right middle occipital gyrus seed and left superior frontal gyrus (green and blue).
Fig.4  Degree centrality of left lingual was positively correlated with FEV1/FVC (%) in patients with asthma (FEV1, forced expiratory volume in the first second; FVC, forced vital capacity).
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