A new perspective in pyroptosis: lifting the veil on GSDMA activation

doi:10.1007/s11684-022-0971-9

Front. Med.

2023, Vol. 17

Issue (3) : 581-583 https://doi.org/10.1007/s11684-022-0971-9

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A new perspective in pyroptosis: lifting the veil on GSDMA activation

Pian Yu, Xiang Chen(

), Cong Peng(

)

Department of Dermatology, Xiangya Hospital, Central South University, Changsha 410008, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha 410008, China; Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Changsha 410008, China; Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Changsha 410008, China; Xiangya Clinical Research Center for Cancer Immunotherapy, Central South University, Changsha 410008, China

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Corresponding Author(s): Xiang Chen,Cong Peng

Just Accepted Date: 25 December 2022 Online First Date: 23 February 2023 Issue Date: 28 July 2023

Cite this article:

Pian Yu,Xiang Chen,Cong Peng. A new perspective in pyroptosis: lifting the veil on GSDMA activation[J]. Front. Med., 2023, 17(3): 581-583.

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https://academic.hep.com.cn/fmd/EN/10.1007/s11684-022-0971-9
https://academic.hep.com.cn/fmd/EN/Y2023/V17/I3/581

Fig.1 Pyroptosis of skin epithelial cells mediated by GAS-SpeB-GSDMA axis. GAS cysteine protease SpeB virulence factor cleaves GSDMA after Gln246 or Gsdma1 after Gln247, which could be abrogated by the cysteine protease inhibitor E64. The N-terminal domain of GSDMA/Gsdma1 (N-GSDMA/N-Gsdma1) could oligomerize to form pores in the cell membrane, further causing lysis and the release of proinflammatory factors, ultimately leading to local inflammation. In addition, SpeB also processes the IL-1β zymogen (pro-IL-1β) to mature IL-1β, which is released extracellular from the pores formed by N-GSDMA/N-Gsdma1.

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