Evolution from genetics to phenotype: reinterpretation of NSCLC plasticity, heterogeneity, and drug resistance

doi:10.1007/s13238-016-0330-1

Protein Cell

2017, Vol. 8

Issue (3) : 178-190 https://doi.org/10.1007/s13238-016-0330-1

REVIEW

Evolution from genetics to phenotype: reinterpretation of NSCLC plasticity, heterogeneity, and drug resistance

Yingjiao Xue^1,^2,^3,⁵,Shenda Hou^1,^2,^3,⁵,Hongbin Ji^1,^2,^3,^4,⁵,Xiangkun Han^1,^2,^3,⁵(

)

¹. Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
². Innovation Center for Cell Signaling Network, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
³. CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
⁴. School of Life Science and Technology, Shanghai Tech University, Shanghai 200120, China
⁵. Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China

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Abstract

Lung cancer is the leading cause of cancer-related deaths worldwide. Targeted therapy is beneficial in most cases, but the development of drug resistance stands as an obstacle to good prognosis. Multiple mechanisms were explored such as genetic alterations, activation of bypass signaling, and phenotypic transition. These intrinsic and/or extrinsic dynamic regulations facilitate tumor cell survival in meeting the demands of signaling under different stimulus. This review introduces lung cancer plasticity and heterogeneity and their correlation with drug resistance. While cancer plasticity and heterogeneity play an essential role in the development of drug resistance, the manipulation of them may bring some inspirations to cancer prognosis and treatment. That is to say, lung cancer plasticity and heterogeneity present us with not only challenges but also opportunities.

Keywords lung cancer plasticity heterogeneity drug resistance phenotypic transition

Corresponding Author(s): Xiangkun Han

Issue Date: 21 March 2017

Cite this article:

Yingjiao Xue,Shenda Hou,Hongbin Ji, et al. Evolution from genetics to phenotype: reinterpretation of NSCLC plasticity, heterogeneity, and drug resistance[J]. Protein Cell, 2017, 8(3): 178-190.

URL:

https://academic.hep.com.cn/pac/EN/10.1007/s13238-016-0330-1
https://academic.hep.com.cn/pac/EN/Y2017/V8/I3/178

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