mTORC1 signaling in hepatic lipid metabolism

doi:10.1007/s13238-017-0409-3

Protein Cell

2018, Vol. 9

Issue (2) : 145-151 https://doi.org/10.1007/s13238-017-0409-3

REVIEW

mTORC1 signaling in hepatic lipid metabolism

Jinbo Han, Yiguo Wang(

)

MOE Key Laboratory of Bioinformatics, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China

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Abstract

The mechanistic target of rapamycin (mTOR) signaling pathway regulates many metabolic and physiological processes in different organs or tissues. Dysregulation of mTOR signaling has been implicated in many human diseases including obesity, diabetes, cancer, fatty liver diseases, and neuronal disorders. Here we review recent progress in understanding how mTORC1 (mTOR complex 1) signaling regulates lipid metabolism in the liver.

Keywords mTOR mTORC1 lipogenesis lipophagy

Corresponding Author(s): Yiguo Wang

Issue Date: 22 March 2018

Cite this article:

Jinbo Han,Yiguo Wang. mTORC1 signaling in hepatic lipid metabolism[J]. Protein Cell, 2018, 9(2): 145-151.

URL:

https://academic.hep.com.cn/pac/EN/10.1007/s13238-017-0409-3
https://academic.hep.com.cn/pac/EN/Y2018/V9/I2/145

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