Research journey of respirasome

doi:10.1007/s13238-019-00681-x

Protein Cell

2020, Vol. 11

Issue (5) : 318-338 https://doi.org/10.1007/s13238-019-00681-x

REVIEW

Research journey of respirasome

Meng Wu¹, Jinke Gu¹, Shuai Zong¹, Runyu Guo¹, Tianya Liu¹, Maojun Yang^1,²(

)

¹. Ministry of Education Key Laboratory of Protein Science, Tsinghua-Peking Joint Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China
². School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

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Abstract

Respirasome, as a vital part of the oxidative phosphorylation system, undertakes the task of transferring electrons from the electron donors to oxygen and produces a proton concentration gradient across the inner mitochondrial membrane through the coupled translocation of protons. Copious research has been carried out on this lynchpin of respiration. From the discovery of individual respiratory complexes to the report of the high-resolution structure of mammalian respiratory supercomplex I₁III₂IV₁, scientists have gradually uncovered the mysterious veil of the electron transport chain (ETC). With the discovery of the mammalian respiratory mega complex I₂III₂IV₂, a new perspective emerges in the research field of the ETC. Behind these advances glitters the light of the revolution in both theory and technology. Here, we give a short review about how scientists ‘see’ the structure and the mechanism of respirasome from the macroscopic scale to the atomic scale during the past decades.

Keywords electron transport chain supercomplex organization cellular respiration structure of respirasome cryo-EM megacomplex

Corresponding Author(s): Maojun Yang

Issue Date: 02 June 2020

Cite this article:

Meng Wu,Jinke Gu,Shuai Zong, et al. Research journey of respirasome[J]. Protein Cell, 2020, 11(5): 318-338.

URL:

https://academic.hep.com.cn/pac/EN/10.1007/s13238-019-00681-x
https://academic.hep.com.cn/pac/EN/Y2020/V11/I5/318

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