Tissue-resident memory-like ILCs: innate counterparts of T<sub>RM</sub> cells

doi:10.1007/s13238-019-0647-7

Protein Cell

2020, Vol. 11

Issue (2) : 85-96 https://doi.org/10.1007/s13238-019-0647-7

REVIEW

Tissue-resident memory-like ILCs: innate counterparts of T_RM cells

Xianwei Wang^1,^2,³, Zhigang Tian^1,^2,³(

), Hui Peng^2,³(

)

¹. The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China
². Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei 230027, China
³. Institue of Immunology, University of Science and Technology of China, Hefei 230027, China

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Abstract

Innate lymphoid cells (ILCs) are deﬁned as lymphocytes that lack RAG recombinase and do not express diverse antigen receptors; however, recent studies have revealed the adaptive features of ILCs. Mouse cytome-galovirus (MCMV)- and cytokine-induced memory natu-ral killer (NK) cells circulate in the blood and are referred to as conventional memory NK cells. In contrast, virus- and hapten-induced memory NK cells, hapten-induced memory ILC1s, and cytokine-induced memory-like ILC2s exhibit long-term residency in the liver or lung, and are referred to as tissue-resident memory ILCs. Considering their similar migration patterns and mem- ory potential, tissue-resident memory ILCs could be regarded as innate counterparts of resident memory T (T_RM) cells. Both tissue-resident memory ILCs and T_RM cells share common characteristics in terms of dynam- ics, phenotype, and molecular regulation. The emer-gence of ILC memory expands the basic biology of ILCs and prompts us to re-examine their functions in disease progression. This review discusses the evidence sup-porting tissue-resident memory NK cells and other memory ILC subsets, compares them with TRM cells, and highlights key unsolved questions in this emerging ﬁeld.

Keywords tissue-residency innate lymphoid cells immunological memory TRM cells

Corresponding Author(s): Zhigang Tian,Hui Peng

Issue Date: 04 March 2020

Cite this article:

Xianwei Wang,Zhigang Tian,Hui Peng. Tissue-resident memory-like ILCs: innate counterparts of T_RM cells[J]. Protein Cell, 2020, 11(2): 85-96.

URL:

https://academic.hep.com.cn/pac/EN/10.1007/s13238-019-0647-7
https://academic.hep.com.cn/pac/EN/Y2020/V11/I2/85

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