Cellular polyploidy in organ homeostasis and regeneration

doi:10.1093/procel/pwac064

Protein Cell

2023, Vol. 14

Issue (8) : 560-578 https://doi.org/10.1093/procel/pwac064

REVIEW

Cellular polyploidy in organ homeostasis and regeneration

Juntao Fang¹, Alain de Bruin^2,³, Andreas Villunger^4,^5,⁶, Raymond Schiffelers⁷, Zhiyong Lei^1,⁷(

), Joost P.G. Sluijter¹(

)

¹. Department of Experimental Cardiology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
². Department of Pediatrics, University of Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands
³. Department of Pathobiology, Dutch Molecular Pathology Center, Utrecht University, Yalelaan1, 3584 CL Utrecht, The Netherlands
⁴. Institute for Developmental Immunology, Biocenter, Medical University of Innsbruck, Innrain 80, 6020 Innsbruck, Austria
⁵. Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Lazarettgasse 14, AKH BT 25.3 c/o CeMM Research Building, Haupteingang Level 1, 1090 Wien, Österreich
⁶. CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14, AKH BT 25.3, A-1090 Vienna, Austria
⁷. CDL Research, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands

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Abstract

Polyploid cells, which contain more than one set of chromosome pairs, are very common in nature. Polyploidy can provide cells with several potential benefits over their diploid counterparts, including an increase in cell size, contributing to organ growth and tissue homeostasis, and improving cellular robustness via increased tolerance to genomic stress and apoptotic signals. Here, we focus on why polyploidy in the cell occurs and which stress responses and molecular signals trigger cells to become polyploid. Moreover, we discuss its crucial roles in cell growth and tissue regeneration in the heart, liver, and other tissues.

Keywords cellular polyploidy tissue regeneration cardiac regeneration liver regeneration

Corresponding Author(s): Zhiyong Lei,Joost P.G. Sluijter

Issue Date: 26 September 2023

Cite this article:

Juntao Fang,Alain de Bruin,Andreas Villunger, et al. Cellular polyploidy in organ homeostasis and regeneration[J]. Protein Cell, 2023, 14(8): 560-578.

URL:

https://academic.hep.com.cn/pac/EN/10.1093/procel/pwac064
https://academic.hep.com.cn/pac/EN/Y2023/V14/I8/560

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