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Protein Cell    2014, Vol. 5 Issue (6) : 420-444    https://doi.org/10.1007/s13238-014-0054-z      PMID: 24756565
REVIEW
Intercellular protein-protein interactions at synapses
Xiaofei Yang1,*(),Dongmei Hou1,2,3,Wei Jiang1,2,3,Chen Zhang2,3,*()
1. Key Laboratory of Cognitive Science, Laboratory of Membrane Ion Channels and Medicine, College of Biomedical Engineering, South-Central University for Nationalities, Wuhan 430074, China
2. State Key Laboratory of Biomembrane and Membrane Biotechnology, College of Life Sciences, Peking University, Beijing 100871, China
3. PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing 100871, China
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Abstract

Chemical synapses are asymmetric intercellular junctions through which neurons send nerve impulses to communicate with other neurons or excitable cells. The appropriate formation of synapses, both spatially and temporally, is essential for brain function and depends on the intercellular protein-protein interactions of cell adhesion molecules (CAMs) at synaptic clefts. The CAM proteins link pre- and post-synaptic sites, and play essential roles in promoting synapse formation and maturation, maintaining synapse number and type, accumulating neurotransmitter receptors and ion channels, controlling neuronal differentiation, and even regulating synaptic plasticity directly. Alteration of the interactions of CAMs leads to structural and functional impairments, which results in many neurological disorders, such as autism, Alzheimer’s disease and schizophrenia. Therefore, it is crucial to understand the functions of CAMs during development and in the mature neural system, as well as in the pathogenesis of some neurological disorders. Here, we review the function of the major classes of CAMs, and how dysfunction of CAMs relates to several neurological disorders.
Keywords synapse formation      cell-cell adhesion      synaptic plasticity      neurological disorders      protein-protein interaction      cell adhesion molecules     
Corresponding Author(s): Xiaofei Yang   
Issue Date: 25 June 2014
 Cite this article:   
Xiaofei Yang,Dongmei Hou,Wei Jiang, et al. Intercellular protein-protein interactions at synapses[J]. Protein Cell, 2014, 5(6): 420-444.
 URL:  
https://academic.hep.com.cn/pac/EN/10.1007/s13238-014-0054-z
https://academic.hep.com.cn/pac/EN/Y2014/V5/I6/420
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