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高校生物学教学研究(电子版)
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高校生物学教学研究  2012, Vol. 2 Issue (1): 20-23
  教改纵横 本期目录
遗传重组率在复杂疾病基因定位中的应用及其拓展
蒋善群,査向东,尹若春
安徽大学生命科学学院,合肥,230039
 全文: PDF(440 KB)  
摘要:基因定位是遗传学研究的重要内容, 也是遗传学教学的重点和难点。本文着重阐述定位人类复杂疾病易感基因的关键方法,包括连锁分析、关联分析、候选基因筛查、全基因组关联分析以及全基因组外显子深度测序等方面,系统地深入地探讨方法的原理及其在复杂疾病的基因定位中的应用。帮助学生深入理解复杂疾病的机理及理论研究方法,为以后从事复杂疾病的遗传学研究奠定理论基础。
关键词 复杂疾病 基因定位 连锁分析 关联分析    
出版日期: 2012-07-25
 引用本文:   
蒋善群,査向东,尹若春. 遗传重组率在复杂疾病基因定位中的应用及其拓展[J]. 高校生物学教学研究, 2012, 2(1): 20-23.
 链接本文:  
https://academic.hep.com.cn/btu/CN/Y2012/V2/I1/20
[1] Swaroop A, Branham KE, ChenW, et al. Genetic susceptibility to age-related macular degeneration: a paradigm for dissecting complex disease traits [J]. Hum Mol Genet, 2007, 16 (2): 174–182.
[2] Dawn Teare M, Barrett JH. Genetic linkage studies [J]. Lancet,2005, 366 (9490) :1036–1044.
[3] Badn er J A, Gershon E S, Gold in L R. Optimal ascertainment strategies to detect linkage to common disease alleles [J]. Am J H um Genet, 1998, 63 (3) : 880–888.
[4] Holmans P. Affected sib pair methods for detecting linkage to dichotomous traits: review of the methodology [J]. Hum Biol,1998, 70 (6) : 1025–1040.
[5] Con sortium T H. A haplotype map of the hum an genome [J].Nature, 2005, 437 (7063) : 1299–1320.
[6] Risch N, Merikangas K. The future of genetic studies of complexhuman diseases [J] . Science, 1996, 273 (5281) : 1516–1517.
[7] Zhang K, Calabrese P, Nordborg M, et al. Haplotype block structure and its applications to association studies: power and study designs [J]. Am J Hum Genet, 2002, 71 (6) : 1386–1394.
[8] Wright A F, Carothers A D, Pirastu M. Population choice in mapp ing genes for comp lex d iseases [J] . Nat Genet, 1999, 23 (4):397–404.
[9] Jones S, Wang TL, Shih IeM, et al. Frequent mutations ofchromatin remodeling gene ARID1A in ovarian clear cell carcinoma [J]. Science, 2010, 330 (6001) : 228–231.
[10] Bowden DW, An SS, Palmer ND, et al. Molecular basis of a linkage peak: exome sequencing and family–based analysis identify a rare genetic variant in the ADIPOQ gene in the IRAS Family Study [J]. Hum Mol Genet, 2010, 19 (20) : 4112–4120.
[11] Bilgüvar K, Özturk AK, Louvi A, et al. Whole-exome sequencing identifies recessive WDR62 mutations in severe brain malformations [J]. Nature, 2010, 467 (7312) : 207–210.
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