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Antitumor mechanism of Se-containing polysaccharide, a novel organic selenium compound |
Dejing SHANG1( ), Qiao CUI1, Yang LI1, Zhi YU1, Lei WEN1, Yuan ZHAO1, Jianing ZHANG2 |
| 1. Liaoning Provincial Key Laboratory of Biotechnology and Drug Discovery, Liaoning Normal University, Dalian 116029, China; 2. College of Basic Medical Sciences, Dalian Medical University, Dalian 116044, China |
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Abstract Recent studies on the inhibition of tumor growth by Se-containing polysaccharide were reviewed. Meanwhile, the possible molecular mechanisms of the inhibition of tumor cell growth through antioxidation, induction of tumor cell apoptosis, blockade of cell cycle, and enhancement of immunity by Se-containing polysaccharide were proposed. In the end, the potential application of Se-containing polysaccharide in the prevention and treatment of tumor was elucidated.
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| Keywords
Se-containing polysaccharide
antitumor
antioxidant
organic selenium
apoptosis
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Corresponding Author(s):
SHANG Dejing,Email:djshang@lnnu.edu.cn
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Issue Date: 05 September 2009
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