Heat shock proteins: Molecules with assorted functions

doi:10.1007/s11515-011-1080-3

Front Biol

2011, Vol. 6

Issue (4) : 312-327 https://doi.org/10.1007/s11515-011-1080-3

REVIEW

Heat shock proteins: Molecules with assorted functions

Surajit SARKAR^1,2(email.png), M. Dhruba SINGH¹, Renu YADAV¹, K. P. ARUNKUMAR², Geoffrey W. PITTMAN²

1. 1. Department of Genetics, University of Delhi, South Campus, Benito Juarez Road, New Delhi-110021, India; 2. 2. Division of Biology, MC156-29, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA

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Abstract

Heat shock proteins (Hsps) or molecular chaperones, are highly conserved protein families present in all studied organisms. Following cellular stress, the intracellular concentration of Hsps generally increases several folds. Hsps undergo ATP-driven conformational changes to stabilize unfolded proteins or unfold them for translocation across membranes or mark them for degradation. They are broadly classified in several families according to their molecular weights and functional properties. Extensive studies during the past few decades suggest that Hsps play a vital role in both normal cellular homeostasis and stress response. Hsps have been reported to interact with numerous substrates and are involved in many biological functions such as cellular communication, immune response, protein transport, apoptosis, cell cycle regulation, gametogenesis and aging. The present review attempts to provide a brief overview of various Hsps and summarizes their involvement in diverse biological activities.

Keywords heat shock protein chaperone chaperonin Hsp100 Hsp90 Hsp70 Hsp60 sHsps fertility apoptosis cytoskeleton

Corresponding Author(s): SARKAR Surajit,Email:sarkar@south.du.ac.in, sarkar@caltech.edu

Issue Date: 01 August 2011

Cite this article:

K. P. ARUNKUMAR,Geoffrey W. PITTMAN,Surajit SARKAR, et al. Heat shock proteins: Molecules with assorted functions[J]. Front Biol, 2011, 6(4): 312-327.

URL:

https://academic.hep.com.cn/fib/EN/10.1007/s11515-011-1080-3
https://academic.hep.com.cn/fib/EN/Y2011/V6/I4/312

Tab.1 Classification of major heat shock proteins (Hsps) based on their proposed biological functions

Fig.1 Confocal images showing distribution of Hsp60 (green) and F-actin (red) in mid-gut muscle (A) and flight muscle (B). Compare to wild type egg chamber (C), mutant egg chamber (D) exhibits abnormal arrangement of F-actin cytoskeleton. OC: Oocyte, NC: Nurse cell.

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