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Frontiers of Medicine

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Front. Med.    2018, Vol. 12 Issue (2) : 130-138    https://doi.org/10.1007/s11684-017-0555-2
REVIEW
Role of brown adipose tissue in metabolic syndrome, aging, and cancer cachexia
Meng Dong1,2, Jun Lin1,2, Wonchung Lim3, Wanzhu Jin1, Hyuek Jong Lee1,4()
1. Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
2. The University of the Chinese Academy of Sciences, Beijing 100049, China
3. Department of Sports Medicine, College of Health Science, Cheongju University, Cheongju 363-764, Republic of Korea
4. Center for Vascular Research, Institute for Basic Science (IBS), Daejeon 34141, Republic of Korea
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Abstract

Brown adipose tissue (BAT) plays a fundamental role in maintaining body temperature by producing heat. BAT that had been know to exist only in mammals and the human neonate has received great attention for the treatment of obesity and diabetes due to its important function in energy metabolism, ever since it is recently reported that human adults have functional BAT. In addition, beige adipocytes, brown adipocytes in white adipose tissue (WAT), have also been shown to take part in whole body metabolism. Multiple lines of evidence demonstrated that transplantation or activation of BAT or/and beige adipocytes reversed obesity and improved insulin sensitivity. Furthermore, many genes involved in BAT activation and/or the recruitment of beige cells have been found, thereby providing new promising strategies for future clinical application of BAT activation to treat obesity and metabolic diseases. This review focuses on recent advances of BAT function in the metabolic aspect and the relationship between BAT and cancer cachexia, a pathological process accompanied with decreased body weight and increased energy expenditure in cancer patients. The underlying possible mechanisms to reduce BAT mass and its activity in the elderly are also discussed.
Keywords brown adipose tissue      beige adipocyte      anti-obesity      anti-diabetes      cancer cachexia      aging     
Corresponding Author(s): Hyuek Jong Lee   
Just Accepted Date: 07 September 2017   Online First Date: 09 November 2017    Issue Date: 02 April 2018
 Cite this article:   
Meng Dong,Jun Lin,Wonchung Lim, et al. Role of brown adipose tissue in metabolic syndrome, aging, and cancer cachexia[J]. Front. Med., 2018, 12(2): 130-138.
 URL:  
https://academic.hep.com.cn/fmd/EN/10.1007/s11684-017-0555-2
https://academic.hep.com.cn/fmd/EN/Y2018/V12/I2/130
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