We propose a novel scheme for measurement-device-independent (MDI) continuous-variable quantum key distribution (CVQKD) by simultaneously conducting classical communication and QKD, which is called “simultaneous MDI-CVQKD” protocol. In such protocol, each sender (Alice, Bob) can superimpose random numbers for QKD on classical information by taking advantage of the same weak coherent pulse and an untrusted third party (Charlie) decodes it by using the same coherent detectors, which could be appealing in practice due to that multiple purposes can be realized by employing only single communication system. What is more, the proposed protocol is MDI, which is immune to all possible side-channel attacks on practical detectors. Security results illustrate that the simultaneous MDI-CVQKD protocol can secure against arbitrary collective attacks. In addition, we employ phasesensitive optical amplifiers to compensate the imperfection existing in practical detectors. With this technology, even common practical detectors can be used for detection through choosing a suitable optical amplifier gain. Furthermore, we also take the finite-size effect into consideration and show that the whole raw keys can be taken advantage of to generate the final secret key instead of sacrificing part of them for parameter estimation. Therefore, an enhanced performance of the simultaneous MDI-CVQKD protocol can be obtained in finite-size regime.