A review of methylenetetrahydrofolate reductase in one-carbon metabolism and psychiatric disorders

doi:10.3868/j.issn.2096-0689.2018.02.002

Journal of Translational Neuroscience

2018, Vol. 3

Issue (2) : 6-12 https://doi.org/10.3868/j.issn.2096-0689.2018.02.002

Review

A review of methylenetetrahydrofolate reductase in one-carbon metabolism and psychiatric disorders

Lin Wan¹, Rena Li^{1, 2, 3*}

1. Beijing Institute for Brain Disorders, Capital Medical University, Beijing 100069, China
2. National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing 100088, China
3. Center for Hormone Advanced Science and Education, Roskamp Institute, Sarasota, FL 34243, USA

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Abstract Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme for the critical process of one-carbon circulation, which convert 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate and participate in folate and homocysteine conversion correlated to methyl group supply. The enzyme activity decline depends on the gene polymorphism. MTHFR impacts on the methylation process which is related to psychiatric diseases. Studies have shown association between MTHFR gene polymorphisms and mental disorders, some of which stratified by folate and cobalamin levels. In this review, we will summarize the testimony on the relationship between methylation and MTHFR polymorphism as well as the implication on psychiatric diseases by MTHFR mutation.

Keywords methylenetetrahydrofolate reductase (MTHFR) polymorphisms DNA methylation psychiatric disorders folate metabolism

Issue Date: 01 October 2018

Cite this article:

Lin Wan, Rena Li. A review of methylenetetrahydrofolate reductase in one-carbon metabolism and psychiatric disorders[J]. Journal of Translational Neuroscience,2018, 3(2): 6-12.

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https://academic.hep.com.cn/jtn/EN/10.3868/j.issn.2096-0689.2018.02.002
https://academic.hep.com.cn/jtn/EN/Y2018/V3/I2/6

[1]	Anthony J Hannan. Optimising validity and translational potential in rodent models of brain disorders[J]. Journal of Translational Neuroscience, 2016, 1(2): 56-62.

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