The role of galectin-4 in physiology and diseases

doi:10.1007/s13238-016-0262-9

Protein Cell

2016, Vol. 7

Issue (5) : 314-324 https://doi.org/10.1007/s13238-016-0262-9

REVIEW

The role of galectin-4 in physiology and diseases

Zhan-Qi Cao,Xiu-Li Guo(

)

Department of Pharmacology, School of Pharmaceutical Sciences, Shandong University, Jinan 50012, China

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Abstract

Galectin-4, a tandem repeat member of the β-galactoside- binding proteins, possesses two carbohydraterecognition domains (CRD) in a single peptide chain. This lectin is mostly expressed in epithelial cells of the intestinal tract and secreted to the extracellular. The two domains have 40% similarity in amino acid sequence, but distinctly binding to various ligands. Just because the two domains bind to different ligands simultaneously, galectin-4 can be a crosslinker and crucial regulator in a large number of biological processes. Recent evidence shows that galectin-4 plays an important role in lipid raft stabilization, protein apical trafficking, cell adhesion, wound healing, intestinal inflammation, tumor progression, etc. This article reviews the physiological and pathological features of galectin-4 and its important role in such processes.

Keywords galectin-4 lipid raft crosslinker intestinal inflammation tumor progression

Corresponding Author(s): Xiu-Li Guo

Issue Date: 27 May 2016

Cite this article:

Zhan-Qi Cao,Xiu-Li Guo. The role of galectin-4 in physiology and diseases[J]. Protein Cell, 2016, 7(5): 314-324.

URL:

https://academic.hep.com.cn/pac/EN/10.1007/s13238-016-0262-9
https://academic.hep.com.cn/pac/EN/Y2016/V7/I5/314

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