Nutri-microbiome epidemiology, an emerging field to disentangle the interplay between nutrition and microbiome for human health

doi:10.1093/procel/pwad023

Protein Cell

2023, Vol. 14

Issue (11) : 787-806 https://doi.org/10.1093/procel/pwad023

REVIEW

Nutri-microbiome epidemiology, an emerging field to disentangle the interplay between nutrition and microbiome for human health

Wanglong Gou^1,^2,³, Zelei Miao^1,^2,³, Kui Deng^1,^2,³, Ju-Sheng Zheng^1,^2,³(

)

¹. Westlake Intelligent Biomarker Discovery Lab, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou 310024, China
². Research Center for Industries of the Future, Key Laboratory of Growth Regulation and Translational Research of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou 310030, China
³. Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, Hangzhou 310024, China

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Abstract

Diet and nutrition have a substantial impact on the human microbiome, and interact with the microbiome, especially gut microbiome, to modulate various diseases and health status. Microbiome research has also guided the nutrition field to a more integrative direction, becoming an essential component of the rising area of precision nutrition. In this review, we provide a broad insight into the interplay among diet, nutrition, microbiome, and microbial metabolites for their roles in the human health. Among the microbiome epidemiological studies regarding the associations of diet and nutrition with microbiome and its derived metabolites, we summarize those most reliable findings and highlight evidence for the relationships between diet and disease-associated microbiome and its functional readout. Then, the latest advances of the microbiome-based precision nutrition research and multidisciplinary integration are described. Finally, we discuss several outstanding challenges and opportunities in the field of nutri-microbiome epidemiology.

Keywords microbiome nutrition human health epidemiology

Corresponding Author(s): Ju-Sheng Zheng

Issue Date: 14 December 2023

Cite this article:

Wanglong Gou,Zelei Miao,Kui Deng, et al. Nutri-microbiome epidemiology, an emerging field to disentangle the interplay between nutrition and microbiome for human health[J]. Protein Cell, 2023, 14(11): 787-806.

URL:

https://academic.hep.com.cn/pac/EN/10.1093/procel/pwad023
https://academic.hep.com.cn/pac/EN/Y2023/V14/I11/787

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