MicroRNA rules: Made to be broken

doi:10.1007/s11515-013-1273-z

Front Biol

2013, Vol. 8

Issue (5) : 468-474 https://doi.org/10.1007/s11515-013-1273-z

MINI-REVIEW

MicroRNA rules: Made to be broken

P. Shannon PENDERGRAST¹(

), Tom VOLPE²(

)

1. Ymir Genomics, 516 Green Street, 1A, Cambridge, MA 02139, USA; 2. Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Chicago, IL 60611, USA

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Abstract

MicroRNAs (miRNAs) are important post-transcriptional regulators of gene expression. For over a decade the deluge of research describing the biogenesis and activity of miRNAs has lead researchers to postulate rules to help make sense of the enormous amount of data produced. These rules are repeated in miRNA research papers and reviews. While these rules have been helpful one must be conscious of their limitations or risk missing future breakthroughs. Here we describe some of the most commonly stated rules, the reasoning behind their formation, their uses, and limitations.

Keywords microRNA post-transcriptional gene regulation mRNA 3' UTR conservation rule seed pairing rule biogenesis rule mechanism of action rule

Corresponding Author(s): PENDERGRAST P. Shannon,Email:shannon@ymirgenomics.com; VOLPE Tom,Email:t-volpe2@northwestern.edu

Issue Date: 01 October 2013

Cite this article:

P. Shannon PENDERGRAST,Tom VOLPE. MicroRNA rules: Made to be broken[J]. Front Biol, 2013, 8(5): 468-474.

URL:

https://academic.hep.com.cn/fib/EN/10.1007/s11515-013-1273-z
https://academic.hep.com.cn/fib/EN/Y2013/V8/I5/468

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