Bioactive compounds from <i>Caulerpa racemosa</i> as a potent larvicidal and antibacterial agent

doi:10.1007/s11515-014-1312-4

Front. Biol.

2014, Vol. 9

Issue (4) : 300-305 https://doi.org/10.1007/s11515-014-1312-4

RESEARCH ARTICLE

Bioactive compounds from Caulerpa racemosa as a potent larvicidal and antibacterial agent

Sowmya Rachannanavar NAGARAJ,Jabez William OSBORNE(

)

School of Biosciences and Technology, VIT University, Vellore- 632014, Tamil Nadu, India

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Abstract

Marine algae are rich sources of bioactive compounds capable of harboring secondary metabolites which are structurally and biologically active. In our study, the methanolic extract of marine algae Caulerpa racemosa (green algae) was employed to determine the antibacterial and larvicidal activity. The antibacterial activity showed effective inhibition against five pathogenic bacteria. A significant zone size of 16 mm was observed for Pseudomonas aeruginosa. The methanolic extract of Caulerpa racemosa showed effective larvicidal activity against Culex tritaeniorhynchus and the histopathological studies revealed the rupture in mid gut of larvae. The bioactive compounds in the crude extract were further identified as 2-(-3-bromo-1-adamantyl) acetic acid methyl ester and Chola-5, 22- dien-3-ol by GC-MS. Hence the bioactive compounds obtained from the methanolic extracts could be used for the bactericidal and larvicidal activity which will overcome the harmful impact of synthetic insecticide on environment.

Keywords marine algae GC-MS antibacterial larvicidal bioactive compounds

Corresponding Author(s): Jabez William OSBORNE

Issue Date: 11 August 2014

Cite this article:

Sowmya Rachannanavar NAGARAJ,Jabez William OSBORNE. Bioactive compounds from Caulerpa racemosa as a potent larvicidal and antibacterial agent[J]. Front. Biol., 2014, 9(4): 300-305.

URL:

https://academic.hep.com.cn/fib/EN/10.1007/s11515-014-1312-4
https://academic.hep.com.cn/fib/EN/Y2014/V9/I4/300

Tab.1 Phytochemical screening of Caulerpa racemosa

Fig.1 Antibacterial activity of methanolic extracts of Caulerpa racemosa.

Tab.2 Effect of methanol extract of Caulerpa racemosa against mosquito larvae

Fig.2 Longitudinal section of untreated Culex tritaeniorhynchus larva.

Fig.3 Longitudinal section of treated Culex tritaeniorhynchus larva.

Fig.4 Chromatogram of Caulerpa racemosa extracts using methanol.

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