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Frontiers of Medicine

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ISSN 2095-0225(Online)

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Front. Med.    2014, Vol. 8 Issue (4) : 404-418    https://doi.org/10.1007/s11684-014-0379-2
REVIEW
Circulating microRNAs in cardiovascular diseases: from biomarkers to therapeutic targets
Feng Wang,Chen Chen,Daowen Wang()
Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
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Abstract

microRNAs (miRNAs) are a class of conserved, short, non-coding RNAs that have important and potent capacities to regulate gene expression at the posttranscriptional level. In the past several years, the aberrant expressions of miRNAs in the cardiovascular system have been widely reported, and the crucial roles of some special miRNAs in heart development and pathophysiology of various cardiovascular diseases have been gradually recognized. Recently, it was discovered that miRNAs are presented in peripheral circulation abundantly and stably. This has raised the possibility of using circulating miRNAs as biomarkers for diseases. Furthermore, some studies demonstrated that circulating miRNAs may serve as novel extracellular communicators of cell-cell communication. These discoveries not only reveal the functions of circulating miRNAs in cardiovascular system but also inform the development of miRNAs therapeutic strategies. In this review, we discuss the potential roles of circulating miRNAs in a variety of cardiovascular diseases from biomarkers to therapeutic targets to clearly understand the roles of circulating miRNAs in cardiovascular system.
Keywords microRNA      cardiovascular disease      biomarkers      therapeutic target     
Corresponding Author(s): Daowen Wang   
Just Accepted Date: 06 November 2014   Online First Date: 01 December 2014    Issue Date: 18 December 2014
 Cite this article:   
Chen Chen,Daowen Wang,Feng Wang. Circulating microRNAs in cardiovascular diseases: from biomarkers to therapeutic targets[J]. Front. Med., 2014, 8(4): 404-418.
 URL:  
https://academic.hep.com.cn/fmd/EN/10.1007/s11684-014-0379-2
https://academic.hep.com.cn/fmd/EN/Y2014/V8/I4/404
Fig.1  Possible interactions of miRNAs between the organs.
Diseases miRNA Patterns Models References
AMI miR-208 Increased ISO ratCAL ratHuman patients [76][68][68, 73]
miR-499 Increased Human patientsAMI mice [66, 69][73]
miR-1 Increased CAL ratHuman patients [77][78]
miR-133 Increased Human patients [66, 79, 81]
HF miR-423-5p Increased Human patients [70]
CAD miR-126,-17,-92a,-155, -145 Decreased Human patients [71]
miR-133a, -208a Increased Human patients [71, 81]
miR-135a Increased Human patients [90]
miR-147 Decreased Human patients [90]
Hypertension hcmv-miR-UL112 Increased Human patients [72]
VM miR-208b, -499 Increased Human patients [73]
Tab.1  Key miRNAs in cardiovascular diseases
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