Role of melatonin in spinal cord injury

doi:10.3868/j.issn.2096-0689.2018.03.004

Journal of Translational Neuroscience

2018, Vol. 3

Issue (3) : 26-31 https://doi.org/10.3868/j.issn.2096-0689.2018.03.004

Review

Role of melatonin in spinal cord injury

Yingli Jing^1,2,3,4, Fan Bai^1,2,3,4, Yan Yu^1,2,3,4*

1.China Rehabilitation Science Institute, Beijing 100068, China
2.China Rehabilitation Research Center, Beijing 100068, China
3.Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing 100069, China
4.Beijing Key Laboratory of Neural Injury and Rehabilitation, Beijing 100068, China

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Abstract Spinal cord injury (SCI) impairs the autonomic nervous system and is associated with dysfunction or failure of multiple organs. Rehabilitation after SCI is a complicated process that involves improvement of motor and sensory function and amelioration of complications. Accumulating evidence has demonstrated that melatonin treatment could protect the neural tissues of the spinal cord from secondary injury after SCI. Melatonin is an indoleamine naturally produced by the pineal gland and other tissues. It can easily cross the blood-brain barrier and has been shown to have neuroprotective properties in animal models with neurological injury, such as traumatic brain injury and SCI. We reviewed the potential mechanisms of melatonin treatment reducing SCI-related complications such as disruption of microcirculation, neurogenic bowel dysfunction, and circadian disorders.

Keywords melatonin spinal cord injury (SCI) neuroprotection microcirculation neurogenic bowel dysfunction circadian disorders

Issue Date: 25 November 2018

Cite this article:

Yingli Jing, Fan Bai, Yan Yu. Role of melatonin in spinal cord injury[J]. Journal of Translational Neuroscience,2018, 3(3): 26-31.

URL:

https://academic.hep.com.cn/jtn/EN/10.3868/j.issn.2096-0689.2018.03.004
https://academic.hep.com.cn/jtn/EN/Y2018/V3/I3/26

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