Regulation of HMGB1 release by inflammasomes

doi:10.1007/s13238-012-2118-2

Prot Cell

2013, Vol. 4

Issue (3) : 163-167 https://doi.org/10.1007/s13238-012-2118-2 PMID: 23483477

MINI-REVIEW

Regulation of HMGB1 release by inflammasomes

Ben Lu^1,2, Haichao Wang³, Ulf Andersson⁴, Kevin J. Tracey¹(

)

1. Laboratory of Biomedical Science, Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, USA; 2. The Elmezzi Graduate School of Molecular Medicine, North Shore-LIJ Health system, 350 Community Drive, Manhasset, NY 11030, USA; 3. Department of Emergency Medicine, North Shore University Hospital, Manhasset, NY 11030, USA; 4. Department of Women’s and Children’s Health, Karolinska Institutet, S-17677 Stockholm, Sweden

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Abstract

High mobility group box 1 (HMGB1) is an evolutionarily conserved non-histone chromatin-binding protein. During infection or injury, activated immune cells and damaged cells release HMGB1 into the extracellular space, where HMGB1 functions as a proinflammatory mediator and contributes importantly to the pathogenesis of infl ammatory diseases. Recent studies reveal that inflammasomes, intracellular protein complexes, critically regulate HMGB1 release from activated immune cells in response to a variety of exogenous and endogenous danger signals. Double stranded RNA dependent kinase (PKR), an intracellular danger-sensing molecule, physically interacts with inflammasome components and is important for inflammasome activation and HMGB1 release. Together, these studies not only unravel novel mechanisms of HMGB1 release during infl ammation, but also provide potential therapeutic targets to treat HMGB1-related infl ammatory diseases.

Keywords HMGB1 inflammasome PKR

Corresponding Author(s): Tracey Kevin J.,Email:kjtracey@nshs.edu

Issue Date: 01 March 2013

Cite this article:

Ben Lu,Ulf Andersson,Kevin J. Tracey, et al. Regulation of HMGB1 release by inflammasomes[J]. Prot Cell, 2013, 4(3): 163-167.

URL:

https://academic.hep.com.cn/pac/EN/10.1007/s13238-012-2118-2
https://academic.hep.com.cn/pac/EN/Y2013/V4/I3/163

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