Inflammasomes in cancer: a double-edged sword

doi:10.1007/s13238-013-0001-4

Protein Cell

2014, Vol. 5

Issue (1) : 12-20 https://doi.org/10.1007/s13238-013-0001-4 PMID: 24474192

REVIEW

Inflammasomes in cancer: a double-edged sword

Ryan Kolb¹,Guang-Hui Liu^2,³,Ann M. Janowski⁴,Fayyaz S. Sutterwala^4,^5,⁶,Weizhou Zhang^1,^*(

)

1. Department of Pathology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
2. National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
3. Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
4. Graduate Program in Immunology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
5. Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
6. Veterans Affairs Medical Center, Iowa City, IA 52241, USA

Download: PDF(197 KB)
Export: BibTeX | EndNote | Reference Manager | ProCite | RefWorks

Abstract

Chronic inflammatory responses have long been observed to be associated with various types of cancer and play decisive roles at different stages of cancer development. Inflammasomes, which are potent inducers of interleukin (IL)-1β and IL-18 during inflammation, are large protein complexes typically consisting of a Nod-like receptor (NLR), the adapter protein ASC, and Caspase-1. During malignant transformation or cancer therapy, the inflammasomes are postulated to become activated in response to danger signals arising from the tumors or from therapy-induced damage to the tumor or healthy tissue. The activation of inflammasomes plays diverse and sometimes contrasting roles in cancer promotion and therapy depending on the specific context. Here we summarize the role of different inflammasome complexes in cancer progression and therapy. Inflammasome components and pathways may provide novel targets to treat certain types of cancer; however, using such agents should be cautiously evaluated due to the complex roles that inflammasomes and proinflammatory cytokines play in immunity.

Keywords inflammasome cancer inflammation

Corresponding Author(s): Weizhou Zhang

Issue Date: 16 May 2014

Cite this article:

Ryan Kolb,Guang-Hui Liu,Ann M. Janowski, et al. Inflammasomes in cancer: a double-edged sword[J]. Protein Cell, 2014, 5(1): 12-20.

URL:

https://academic.hep.com.cn/pac/EN/10.1007/s13238-013-0001-4
https://academic.hep.com.cn/pac/EN/Y2014/V5/I1/12

1	AllenIC, TeKippeEM, WoodfordRM, UronisJM, HollEK, RogersAB, HerfarthHH, JobinC, TingJP (2010) The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer. J Exp Med207: 1045-1056 doi: 10.1084/jem.20100050
2	AllenIC, WilsonJE, SchneiderM, LichJD, RobertsRA, ArthurJC, WoodfordRM, DavisBK, UronisJM, HerfarthHH (2012) NLRP12 suppresses colon inflammation and tumorigenesis through the negative regulation of noncanonical NF-κB signaling. Immunity36: 742-754 doi: 10.1016/j.immuni.2012.03.012
3	BassoD, ScrignerM, TomaA, NavagliaF, Di MarioF, RuggeM, PlebaniM (1996) Helicobacter pylori infection enhances mucosal interleukin-1 beta, interleukin-6, and the soluble receptor of interleukin-2. Int J Clin Lab Res26: 207-210 doi: 10.1007/BF02592984
4	BauerC, DuewellP, MayerC, LehrHA, FitzgeraldKA, DauerM, TschoppJ, EndresS, LatzE, SchnurrM (2010) Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome. Gut59: 1192-1199 doi: 10.1136/gut.2009.197822
5	BauernfeindF, HornungV (2013) Of inflammasomes and pathogens -sensing of microbes by the inflammasome. EMBO Mol Med5: 814-826 doi: 10.1002/emmm.201201771
6	BauernfeindFG, HorvathG, StutzA, AlnemriES, MacDonaldK, SpeertD, Fernandes-AlnemriT, WuJ, MonksBG, FitzgeraldKA (2009) Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression. J Immunol183: 787-791 doi: 10.4049/jimmunol.0901363
7	BauernfeindF, AblasserA, BartokE, KimS, Schmid-BurgkJ, CavlarT, HornungV (2011) Inflammasomes: current understanding and open questions. Cell Mol Life Sci68: 765-783 doi: 10.1007/s00018-010-0567-4
8	BuntSK, ClementsVK, HansonEM, SinhaP, Ostrand-RosenbergS (2009) Inflammation enhances myeloid-derived suppressor cell cross-talk by signaling through Toll-like receptor 4. J Leukoc Biol85: 996-1004 doi: 10.1189/jlb.0708446
9	BurdetteD, HaskettA, PresserL, McRaeS, IqbalJ, WarisG (2012) Hepatitis C virus activates interleukin-1beta via caspase-1- inflammasome complex. J Gen Virol93: 235-246 doi: 10.1099/vir.0.034033-0
10	ChaveyC, BibeauF, Gourgou-BourgadeS, BurlinchonS, BoissiereF, LauneD, RoquesS, LazennecG (2007) Oestrogen receptor negative breast cancers exhibit high cytokine content. Breast Cancer Res9: R15 doi: 10.1186/bcr1648
11	ChenGY, NunezG (2011) Inflammasomes in intestinal inflammation and cancer. Gastroenterology141: 1986-1999 doi: 10.1053/j.gastro.2011.10.002
12	ChenGY, LiuM, WangF, BertinJ, NunezG (2011) A functional role for Nlrp6 in intestinal inflammation and tumorigenesis. J Immunol186: 7187-7194 doi: 10.4049/jimmunol.1100412
13	ChowMT, SceneayJ, PagetC, WongCS, DuretH, TschoppJ, MollerA, SmythMJ (2012) NLRP3 suppresses NK cell-mediated responses to carcinogen-induced tumors and metastases. Cancer Res72: 5721-5732 doi: 10.1158/0008-5472.CAN-12-0509
14	CoussensLM, ZitvogelL, PaluckaAK (2013) Neutralizing tumorpromoting chronic inflammation: a magic bullet? Science339: 286-291 doi: 10.1126/science.1232227
15	Di VirgilioF (2013) The therapeutic potential of modifying inflammasomes and NOD-Like receptors. Pharmacol Rev65: 872-905 doi: 10.1124/pr.112.006171
16	DinarelloCA (2009) Immunological and inflammatory functions of the interleukin-1 family. Annu Rev Immunol27: 519-550 doi: 10.1146/annurev.immunol.021908.132612
17	DinarelloCA (2011) Interleukin-1 in the pathogenesis and treatment of inflammatory diseases. Blood117: 3720-3732 doi: 10.1182/blood-2010-07-273417
18	DostertC, PetrilliV, Van BruggenR, SteeleC, MossmanBT, TschoppJ (2008) Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica. Science320: 674-677 doi: 10.1126/science.1156995
19	DrexlerSK, BonsignoreL, MasinM, TardivelA, JackstadtR, HermekingH, SchneiderP, GrossO, TschoppJ, YazdiAS (2012) Tissue-speciflc opposing functions of the inflammasome adaptor ASC in the regulation of epithelial skin carcinogenesis. Proc Natl Acad Sci USA109: 18384-18389 doi: 10.1073/pnas.1209171109
20	DunnJH, EllisLZ, FujitaM (2012) Inflammasomes as molecular mediators of inflammation and cancer: potential role in melanoma. Cancer Lett314: 24-33 doi: 10.1016/j.canlet.2011.10.001
21	Dupaul-ChicoineJ, YeretssianG, DoironK, BergstromKS, McIntireCR, LeBlancPM, MeunierC, TurbideC, GrosP, BeaucheminN (2010) Control of intestinal homeostasis, colitis, and colitisassociated colorectal cancer by the inflammatory caspases. Immunity32: 367-378 doi: 10.1016/j.immuni.2010.02.012
22	EisenbarthSC, FlavellRA (2009) Innate instruction of adaptive immunity revisited: the inflammasome. EMBO Mol Med1: 92-98 doi: 10.1002/emmm.200900014
23	ElinavE, StrowigT, KauAL, Henao-MejiaJ, ThaissCA, BoothCJ, PeaperDR, BertinJ, EisenbarthSC, GordonJI (2011) NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis. Cell145: 745-757 doi: 10.1016/j.cell.2011.04.022
24	ElkabetsM, RibeiroVS, DinarelloCA, Ostrand-RosenbergS, Di SantoJP, ApteRN, VosshenrichCA (2010) IL-1beta regulates a novel myeloid-derived suppressor cell subset that impairs NK cell development and function. Eur J Immunol40: 3347-3357 doi: 10.1002/eji.201041037
25	ElliottMR, ChekeniFB, TrampontPC, LazarowskiER, KadlA, WalkSF, ParkD, WoodsonRI, OstankovichM, SharmaP (2009) Nucleotides released by apoptotic cells act as a flnd-me signal to promote phagocytic clearance. Nature461: 282-286 doi: 10.1038/nature08296
26	El-OmarEM, CarringtonM, ChowWH, McCollKE, BreamJH, YoungHA, HerreraJ, LissowskaJ, YuanCC, RothmanN (2000) Interleukin-1 polymorphisms associated with increased risk of gastric cancer. Nature404: 398-402 doi: 10.1038/35006081
27	Fernandes-AlnemriT, YuJW, DattaP, WuJ, AlnemriES (2009) AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA. Nature458: 509-513 doi: 10.1038/nature07710
28	Fernandes-AlnemriT, YuJW, JulianaC, SolorzanoL, KangS, WuJ, DattaP, McCormickM, HuangL, McDermottE (2010) The AIM2 inflammasome is critical for innate immunity to Francisella tularensis. Nat Immunol11: 385-393 doi: 10.1038/ni.1859
29	FerroneC, DranoffG (2010) Dual roles for immunity in gastrointestinal cancers. J Clin Oncol28: 4045-4051 doi: 10.1200/JCO.2010.27.9992
30	FranchiL, NunezG (2012) Immunology. Orchestrating inflammasomes. Science337: 1299-1300 doi: 10.1126/science.1229010
31	FranchiL, AmerA, Body-MalapelM, KannegantiTD, OzorenN, JagirdarR, InoharaN, VandenabeeleP, BertinJ, CoyleA (2006) Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages. Nat Immunol7: 576-582 doi: 10.1038/ni1346
32	GhiringhelliF, ApetohL, TesniereA, AymericL, MaY, OrtizC, VermaelenK, PanaretakisT, MignotG, UllrichE (2009) Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors. Nat Med15: 1170-1178 doi: 10.1038/nm.2028
33	GreenDR, KroemerG (2005) Pharmacological manipulation of cell death: clinical applications in sight? J Clin Invest115: 2610-2617 doi: 10.1172/JCI26321
34	GringhuisSI, KapteinTM, WeversBA, TheelenB, van der VlistM, BoekhoutT, GeijtenbeekTB (2012) Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1beta via a noncanonical caspase-8 inflammasome. Nat Immunol13: 246-254 doi: 10.1038/ni.2222
35	GrivennikovSI, GretenFR, KarinM (2010) Immunity, inflammation, and cancer. Cell140: 883-899 doi: 10.1016/j.cell.2010.01.025
36	HornungV, AblasserA, Charrel-DennisM, BauernfeindF, HorvathG, CaffreyDR, LatzE, FitzgeraldKA (2009) AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC. Nature458: 514-518 doi: 10.1038/nature07725
37	HuB, ElinavE, HuberS, BoothCJ, StrowigT, JinC, EisenbarthSC, FlavellRA (2010) Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4. Proc Natl Acad Sci USA107: 21635-21640 doi: 10.1073/pnas.1016814108
38	HuB, ElinavE, FlavellRA (2011) Inflammasome-mediated suppression of inflammation-induced colorectal cancer progression is mediated by direct regulation of epithelial cell proliferation. Cell Cycle10: 1936-1939 doi: 10.4161/cc.10.12.16008
39	IdzkoM, DichmannS, FerrariD, Di VirgilioF, la SalaA, GirolomoniG, PantherE, NorgauerJ (2002) Nucleotides induce chemotaxis and actin polymerization in immature but not mature human dendritic cells via activation of pertussis toxin-sensitive P2y receptors. Blood100: 925-932 doi: 10.1182/blood.V100.3.925
40	IyerSS, PulskensWP, SadlerJJ, ButterLM, TeskeGJ, UllandTK, EisenbarthSC, FlorquinS, FlavellRA, LeemansJC (2009) Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome. Proc Natl Acad Sci USA106: 20388-20393 doi: 10.1073/pnas.0908698106
41	JeeCD, LeeHS, BaeSI, YangHK, LeeYM, RhoMS, KimWH (2005) Loss of caspase-1 gene expression in human gastric carcinomas and cell lines. Int J Oncol26: 1265-1271
42	JinL, YuanRQ, FuchsA, YaoY, JosephA, SchwallR, SchnittSJ, GuidaA, HastingsHM, AndresJ (1997) Expression of interleukin-1beta in human breast carcinoma. Cancer80: 421-434 doi: 10.1002/(SICI)1097-0142(19970801)80:3<421::AID-CNCR10>3.0.CO;2-Z
43	JulianaC, Fernandes-AlnemriT, KangS, FariasA, QinF, AlnemriES (2012) Non-transcriptional priming and deubiquitination regulate NLRP3 inflammasome activation. J Biol Chem287: 36617-36622 doi: 10.1074/jbc.M112.407130
44	KanavyHE, GerstenblithMR (2011) Ultraviolet radiation and melanoma. Semin Cutan Med Surg30: 222-228 doi: 10.1016/j.sder.2011.08.003
45	KayagakiN, WarmingS, LamkanflM, Vande WalleL, LouieS, DongJ, NewtonK, QuY, LiuJ, HeldensS (2011) Non-canonical inflammasome activation targets caspase-11. Nature479: 117-121 doi: 10.1038/nature10558
46	KimS, BauernfeindF, AblasserA, HartmannG, FitzgeraldKA, LatzE, HornungV (2010) Listeria monocytogenes is sensed by the NLRP3 and AIM2 inflammasome. Eur J Immunol40: 1545-1551 doi: 10.1002/eji.201040425
47	LamkanflM, DixitVM (2009) The inflammasomes. PLoS Pathog5: e1000510 doi: 10.1371/journal.ppat.1000510
48	LiY, WangL, PappanL, Galliher-BeckleyA, ShiJ (2012) IL-1beta promotes stemness and invasiveness of colon cancer cells through Zeb1 activation. Mol Cancer11: 87 doi: 10.1186/1476-4598-11-87
49	LiuX, WangZ, YuJ, LeiG, WangS (2010) Three polymorphisms in interleukin-1beta gene and risk for breast cancer: a metaanalysis. Breast Cancer Res Treat124: 821-825 doi: 10.1007/s10549-010-0910-3
50	LiuW, LuoY, DunnJH, NorrisDA, DinarelloCA, FujitaM (2013) Dual role of apoptosis-associated speck-like protein containing a CARD (ASC) in tumorigenesis of human melanoma. J Invest Dermatol133: 518-527 doi: 10.1038/jid.2012.317
51	LocherC, ConfortiR, AymericL, MaY, YamazakiT, RusakiewiczS, TesniereA, GhiringhelliF, ApetohL, MorelY (2010) Desirable cell death during anticancer chemotherapy. Ann N Y Acad Sci1209: 99-108 doi: 10.1111/j.1749-6632.2010.05763.x
52	MachadoJC, PharoahP, SousaS, CarvalhoR, OliveiraC, FigueiredoC, AmorimA, SerucaR, CaldasC, CarneiroF (2001) Interleukin 1B and interleukin 1RN polymorphisms are associated with increased risk of gastric carcinoma. Gastroenterology121: 823-829 doi: 10.1053/gast.2001.28000
53	MariathasanS, NewtonK, MonackDM, VucicD, FrenchDM, LeeWP, Roose-GirmaM, EricksonS, DixitVM (2004) Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf. Nature430: 213-218 doi: 10.1038/nature02664
54	MariathasanS, WeissDS, NewtonK, McBrideJ, O’RourkeK, Roose-GirmaM, LeeWP, WeinrauchY, MonackDM, DixitVM (2006) Cryopyrin activates the inflammasome in response to toxins and ATP. Nature440: 228-232 doi: 10.1038/nature04515
55	MartinonF, PetrilliV, MayorA, TardivelA, TschoppJ (2006) Goutassociated uric acid crystals activate the NALP3 inflammasome. Nature440: 237-241 doi: 10.1038/nature04516
56	MartinsI, TesniereA, KeppO, MichaudM, SchlemmerF, SenovillaL, SerorC, MetivierD, PerfettiniJL, ZitvogelL (2009) Chemotherapy induces ATP release from tumor cells. Cell Cycle8: 3723-3728 doi: 10.4161/cc.8.22.10026
57	MattarolloSR, LoiS, DuretH, MaY, ZitvogelL, SmythMJ (2011) Pivotal role of innate and adaptive immunity in anthracycline chemotherapy of established tumors. Cancer Res71: 4809-4820 doi: 10.1158/0008-5472.CAN-11-0753
58	McNamaraD, El-OmarE (2008) Helicobacter pylori infection and the pathogenesis of gastric cancer: a paradigm for host-bacterial interactions. Dig Liver Dis40: 504-509 doi: 10.1016/j.dld.2008.02.031
59	MiaoEA, Alpuche-ArandaCM, DorsM, ClarkAE, BaderMW, MillerSI, AderemA (2006) Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf. Nat Immunol7: 569-575 doi: 10.1038/ni1344
60	MiaoEA, ErnstRK, DorsM, MaoDP, AderemA (2008) Pseudomonas aeruginosa activates caspase 1 through Ipaf. Proc Natl Acad Sci USA105: 2562-2567 doi: 10.1073/pnas.0712183105
61	MiaoEA, RajanJV, AderemA (2011) Caspase-1-induced pyroptotic cell death. Immunol Rev243: 206-214 doi: 10.1111/j.1600-065X.2011.01044.x
62	NegashAA, RamosHJ, CrochetN, LauDT, DoehleB, PapicN, DelkerDA, JoJ, BertolettiA, HagedornCH (2013) IL-1beta production through the NLRP3 inflammasome by hepatic macrophages links hepatitis C virus infection with liver inflammation and disease. PLoS Pathog9: e1003330 doi: 10.1371/journal.ppat.1003330
63	NormandS, Delanoye-CrespinA, BressenotA, HuotL, GrandjeanT, Peyrin-BirouletL, LemoineY, HotD, ChamaillardM (2011) Nodlike receptor pyrin domain-containing protein 6 (NLRP6) controls epithelial self-renewal and colorectal carcinogenesis upon injury. Proc Natl Acad Sci USA108: 9601-9606 doi: 10.1073/pnas.1100981108
64	OkamotoM, LiuW, LuoY, TanakaA, CaiX, NorrisDA, DinarelloCA, FujitaM (2010) Constitutively active inflammasome in human melanoma cells mediating autoinflammation via caspase-1 processing and secretion of interleukin-1beta. J Biol Chem285: 6477-6488 doi: 10.1074/jbc.M109.064907
65	PantschenkoAG, PushkarI, AndersonKH, WangY, MillerLJ, KurtzmanSH, BarrowsG, KreutzerDL (2003) The interleukin-1 family of cytokines and receptors in human breast cancer: implications for tumor progression. Int J Oncol23: 269-284
66	RamanD, BaugherPJ, ThuYM, RichmondA (2007) Role of chemokines in tumor growth. Cancer Lett256: 137-165 doi: 10.1016/j.canlet.2007.05.013
67	RathinamVA, JiangZ, WaggonerSN, SharmaS, ColeLE, WaggonerL, VanajaSK, MonksBG, GanesanS, LatzE (2010) The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses. Nat Immunol11: 395-402 doi: 10.1038/ni.1864
68	ReedJR, LeonRP, HallMK, SchwertfegerKL (2009) Interleukin-1beta and flbroblast growth factor receptor 1 cooperate to induce cyclooxygenase-2 during early mammary tumourigenesis. Breast Cancer Res11:R21 doi: 10.1186/bcr2246
69	SagulenkoV, ThygesenSJ, SesterDP, IdrisA, CridlandJA, VajjhalaPR, RobertsTL, SchroderK, VinceJE, HillJM (2013) AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC. Cell Death Differ20: 1149-1160 doi: 10.1038/cdd.2013.37
70	SakuraiT, HeG, MatsuzawaA, YuGY, MaedaS, HardimanG, KarinM (2008) Hepatocyte necrosis induced by oxidative stress and IL-1 alpha release mediate carcinogen-induced compensatory proliferation and liver tumorigenesis. Cancer Cell14: 156-165 doi: 10.1016/j.ccr.2008.06.016
71	SalcedoR, WorschechA, CardoneM, JonesY, GyulaiZ, DaiRM, WangE, MaW, HainesD, O’HUiginC (2010) MyD88- mediated signaling prevents development of adenocarcinomas of the colon: role of interleukin 18. J Exp Med207: 1625-1636 doi: 10.1084/jem.20100199
72	SchroderK, TschoppJ (2010) The inflammasomes. Cell140: 821-832 doi: 10.1016/j.cell.2010.01.040
73	SchroderK, SagulenkoV, ZamoshnikovaA, RichardsAA, CridlandJA, IrvineKM, StaceyKJ, SweetMJ (2012) Acute lipopolysaccharide priming boosts inflammasome activation independently of inflammasome sensor induction. Immunobiology217: 1325-1329 doi: 10.1016/j.imbio.2012.07.020
74	SevkoA, UmanskyV (2013) Myeloid-derived suppressor cells interact with tumors in terms of myelopoiesis, tumorigenesis and immunosuppression: thick as thieves. J Cancer4: 3-11 doi: 10.7150/jca.5047
75	SiegmundB, LehrHA, FantuzziG, DinarelloCA (2001) IL-1 betaconverting enzyme (caspase-1) in intestinal inflammation. Proc Natl Acad Sci USA98: 13249-13254 doi: 10.1073/pnas.231473998
76	SnoussiK, StrosbergAD, BouaouinaN, Ben AhmedS, ChouchaneL (2005) Genetic variation in pro-inflammatory cytokines (interleukin-1beta, interleukin-1alpha and interleukin-6) associated with the aggressive forms, survival, and relapse prediction of breast carcinoma. Eur Cytokine Netw16: 253-260
77	SrivastavaS, SalimN, RobertsonMJ (2010) Interleukin-18: biology and role in the immunotherapy of cancer. Curr Med Chem17: 3353-3357 doi: 10.2174/092986710793176348
78	StehlikC, FiorentinoL, DorfleutnerA, BrueyJM, ArizaEM, SagaraJ, ReedJC (2002) The PAAD/PYRIN-family protein ASC is a dual regulator of a conserved step in nuclear factor kappaB activation pathways. J Exp Med196: 1605-1615 doi: 10.1084/jem.20021552
79	SuzukiT, FranchiL, TomaC, AshidaH, OgawaM, YoshikawaY, MimuroH, InoharaN, SasakawaC, NunezG (2007) Differential regulation of caspase-1 activation, pyroptosis, and autophagy via Ipaf and ASC in Shigella-infected macrophages. PLoS Pathog3: e111 doi: 10.1371/journal.ppat.0030111
80	TermeM, UllrichE, AymericL, MeinhardtK, DesboisM, DelahayeN, ViaudS, RyffelB, YagitaH, KaplanskiG (2011) IL-18 induces PD-1-dependent immunosuppression in cancer. Cancer Res71: 5393-5399 doi: 10.1158/0008-5472.CAN-11-0993
81	TuS, BhagatG, CuiG, TakaishiS, Kurt-JonesEA, RickmanB, BetzKS, Penz-OesterreicherM, BjorkdahlO, FoxJG (2008) Overexpression of interleukin-1beta induces gastric inflammation and cancer and mobilizes myeloid-derived suppressor cells in mice. Cancer Cell14: 408-419 doi: 10.1016/j.ccr.2008.10.011
82	van DeventerHW, BurgentsJE, WuQP, WoodfordRM, BrickeyWJ, AllenIC, McElvania-TekippeE, SerodyJS, TingJP (2010) The inflammasome component NLRP3 impairs antitumor vaccine by enhancing the accumulation of tumor-associated myeloid-derived suppressor cells. Cancer Res70: 10161-10169 doi: 10.1158/0008-5472.CAN-10-1921
83	WangP, XiaHH, ZhangJY, DaiLP, XuXQ, WangKJ (2007) Association of interleukin-1 gene polymorphisms with gastric cancer: a meta-analysis. Int J Cancer120: 552-562 doi: 10.1002/ijc.22353
84	ZakiMH, BoydKL, VogelP, KastanMB, LamkanflM, KannegantiTD (2010a) The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis. Immunity32: 379-391 doi: 10.1016/j.immuni.2010.03.003
85	ZakiMH, VogelP, Body-MalapelM, LamkanflM, KannegantiTD (2010b) IL-18 production downstream of the Nlrp3 inflammasome confers protection against colorectal tumor formation. J Immunol185: 4912-4920 doi: 10.4049/jimmunol.1002046
86	ZakiMH, VogelP, MalireddiRK, Body-MalapelM, AnandPK, BertinJ, GreenDR, LamkanflM, KannegantiTD (2011) The NOD-like receptor NLRP12 attenuates colon inflammation and tumorigenesis. Cancer Cell20: 649-660 doi: 10.1016/j.ccr.2011.10.022
87	ZamboniDS, KobayashiKS, KohlsdorfT, OguraY, LongEM, VanceRE, KuidaK, MariathasanS, DixitVM, FlavellRA (2006) The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection. Nat Immunol7: 318-325 doi: 10.1038/ni1305
88	ZhuY, ZhuM, LanceP (2012) IL1beta-mediated Stromal COX-2 signaling mediates proliferation and invasiveness of colonic epithelial cancer cells. Exp Cell Res318: 2520-2530 doi: 10.1016/j.yexcr.2012.07.021
89	ZitvogelL, KeppO, GalluzziL, KroemerG (2012) Inflammasomes in carcinogenesis and anticancer immune responses. Nat Immunol13: 343-351 doi: 10.1038/ni.2224

[1]	Mona Teng, Stanley Zhou, Changmeng Cai, Mathieu Lupien, Housheng Hansen He. Pioneer of prostate cancer: past, present and the future of FOXA1[J]. Protein Cell, 2021, 12(1): 29-38.
[2]	Matthieu Talagas, Nicolas Lebonvallet, François Berthod, Laurent Misery. Lifting the veil on the keratinocyte contribution to cutaneous nociception[J]. Protein Cell, 2020, 11(4): 239-250.
[3]	Henry Y. Jiang, Sara Najmeh, Guy Martel, Elyse MacFadden-Murphy, Raquel Farias, Paul Savage, Arielle Leone, Lucie Roussel, Jonathan Cools-Lartigue, Stephen Gowing, Julie Berube, Betty Giannias, France Bourdeau, Carlos H. F. Chan, Jonathan D. Spicer, Rebecca McClure, Morag Park, Simon Rousseau, Lorenzo E. Ferri. Activation of the pattern recognition receptor NOD1 augments colon cancer metastasis[J]. Protein Cell, 2020, 11(3): 187-201.
[4]	Ruyi Xu, Yi Li, Yang Liu, Jianwei Qu, Wen Cao, Enfan Zhang, Jingsong He, Zhen Cai. How are MCPIP1 and cytokines mutually regulated in cancer-related immunity?[J]. Protein Cell, 2020, 11(12): 881-893.
[5]	Weiwei Jiang, Fangfang Cai, Huangru Xu, Yanyan Lu, Jia Chen, Jia Liu, Nini Cao, Xiangyu Zhang, Xiao Chen, Qilai Huang, Hongqin Zhuang, Zi-Chun Hua. Extracellular signal regulated kinase 5 promotes cell migration, invasion and lung metastasis in a FAK-dependent manner[J]. Protein Cell, 2020, 11(11): 825-845.
[6]	Fenjie Li, Junjun Ding. Sialylation is involved in cell fate decision during development, reprogramming and cancer progression[J]. Protein Cell, 2019, 10(8): 550-565.
[7]	Daisuke Aki, Qian Li, Hui Li, Yun-Cai Liu, Jee Ho Lee. Immune regulation by protein ubiquitination: roles of the E3 ligases VHL and Itch[J]. Protein Cell, 2019, 10(6): 395-404.
[8]	Wei Shao, Shasha Li, Lu Li, Kequan Lin, Xinhong Liu, Haiyan Wang, Huili Wang, Dong Wang. Chemical genomics reveals inhibition of breast cancer lung metastasis by Ponatinib via c-Jun[J]. Protein Cell, 2019, 10(3): 161-177.
[9]	Boyi Zhang, Fei Chen, Qixia Xu, Liu Han, Jiaqian Xu, Libin Gao, Xiaochen Sun, Yiwen Li, Yan Li, Min Qian, Yu Sun. Revisiting ovarian cancer microenvironment: a friend or a foe?[J]. Protein Cell, 2018, 9(8): 674-692.
[10]	Yelei Guo, Kaichao Feng, Yao Wang, Weidong Han. Targeting cancer stem cells by using chimeric antigen receptor-modified T cells: a potential and curable approach for cancer treatment[J]. Protein Cell, 2018, 9(6): 516-526.
[11]	Jia Yang, Jun Yu. The association of diet, gut microbiota and colorectal cancer: what we eat may imply what we get[J]. Protein Cell, 2018, 9(5): 474-487.
[12]	Xiao-xiao Xu, Han Wan, Li Nie, Tong Shao, Li-xin Xiang, Jian-zhong Shao. RIG-I: a multifunctional protein beyond a pattern recognition receptor[J]. Protein Cell, 2018, 9(3): 246-253.
[13]	Nicole M. Anderson, Patrick Mucka, Joseph G. Kern, Hui Feng. The emerging role and targetability of the TCA cycle in cancer metabolism[J]. Protein Cell, 2018, 9(2): 216-237.
[14]	John M. Dean, Irfan J. Lodhi. Structural and functional roles of ether lipids[J]. Protein Cell, 2018, 9(2): 196-206.
[15]	Ping Wang, Zunpeng Liu, Xiaoqian Zhang, Jingyi Li, Liang Sun, Zhenyu Ju, Jian Li, Piu Chan, Guang-Hui Liu, Weiqi Zhang, Moshi Song, Jing Qu. CRISPR/Cas9-mediated gene knockout reveals a guardian role of NF-κB/RelA in maintaining the homeostasis of human vascular cells[J]. Protein Cell, 2018, 9(11): 945-965.

Viewed

Full text

Abstract

Cited

Shared

Discussed