Lifting the veil on the keratinocyte contribution to cutaneous nociception

doi:10.1007/s13238-019-00683-9

Protein Cell

2020, Vol. 11

Issue (4) : 239-250 https://doi.org/10.1007/s13238-019-00683-9

REVIEW

Lifting the veil on the keratinocyte contribution to cutaneous nociception

Matthieu Talagas^1,^2,^3,⁴(

), Nicolas Lebonvallet^1,⁴, François Berthod², Laurent Misery^1,^3,⁴

¹. Univ Brest, LIEN, 29200 Brest, France
². Laboratoire d’Organogenèse Expérimentale (LOEX), University of Laval, Quebec, Canada
³. Department of Dermatology, Brest University Hospital, Brest, France
⁴. Univ Brest, IBSAM (Institut Brestois de Santé Agro matière), 29200 Brest, France

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Abstract

Cutaneous nociception is essential to prevent individuals from sustaining injuries. According to the conventional point of view, the responses to noxious stimuli are thought to be exclusively initiated by sensory neurons, whose activity would be at most modulated by keratinocytes. However recent studies have demonstrated that epidermal keratinocytes can also act as primary nociceptive transducers as a supplement to sensory neurons. To enlighten our understanding of cutaneous nociception, this review highlights recent and relevant ﬁndings on the cellular and molecular elements that underlie the contribution of epidermal keratinocytes as nociceptive modulators and noxious sensors, both under healthy and pathological conditions.

Keywords keratinocyte nociception skin TRP pain inflammation

Corresponding Author(s): Matthieu Talagas

Issue Date: 06 May 2020

Cite this article:

Matthieu Talagas,Nicolas Lebonvallet,François Berthod, et al. Lifting the veil on the keratinocyte contribution to cutaneous nociception[J]. Protein Cell, 2020, 11(4): 239-250.

URL:

https://academic.hep.com.cn/pac/EN/10.1007/s13238-019-00683-9
https://academic.hep.com.cn/pac/EN/Y2020/V11/I4/239

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