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EZH2, an epigenetic driver of prostate cancer |
Yeqing Angela Yang1, Jindan Yu1,2( ) |
| 1. Division of Hematology/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA; 2. Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA |
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Abstract The histone methyltransferase EZH2 has been in the limelight of the fi eld of cancer epigenetics for a decade now since it was fi rst discovered to exhibit an elevated expression in metastatic prostate cancer. It persists to attract much scientifi c attention due to its important role in the process of cancer development and its potential of being an effective therapeutic target. Thus here we review the dysregulation of EZH2 in prostate cancer, its function, upstream regulators, downstream effectors, and current status of EZH2-targeting approaches. This review therefore provides a comprehensive overview of EZH2 in the context of prostate cancer.
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| Keywords
EZH2
histone methyltransferase
prostate cancer
epigenetics
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Corresponding Author(s):
Yu Jindan,Email:jindan-yu@northwestern.edu
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Issue Date: 01 May 2013
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