IL-2 and IL-15 dependent thymic development of Foxp3-expressing regulatory T lymphocytes

doi:10.1007/s13238-017-0425-3

Protein Cell

2018, Vol. 9

Issue (4) : 322-332 https://doi.org/10.1007/s13238-017-0425-3

REVIEW

IL-2 and IL-15 dependent thymic development of Foxp3-expressing regulatory T lymphocytes

Cécile Apert, Paola Romagnoli(

), Joost P. M. van Meerwijk(

)

CPTP, Université de Toulouse, CNRS, Inserm, UPS, Toulouse, France

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Abstract

Immunosuppressive regulatory T lymphocytes (Treg) expressing the transcription factor Foxp3 play a vital role in the maintenance of tolerance of the immunesystem to self and innocuous non-self. Most Treg that are critical for the maintenance of tolerance to self, develop as an independent T-cell lineage from common T cell precursors in the thymus. In this organ, their differentiation requires signals from the T cell receptor for antigen, from co-stimulatory molecules, as well as from cytokine-receptors. Here we focus on the cytokines implicated in thymic development of Treg, with a particular emphasis on the roles of interleukin-2 (IL-2) and IL-15. The more recently appreciated involvement of TGF-β in thymic Treg development is also briefly discussed. Finally, we discuss how cytokine-dependence of Treg development allows for temporal, quantitative, and potentially qualitative modulation of this process.

Keywords regulatory T cells thymus differentiation IL-2 IL-15

Corresponding Author(s): Paola Romagnoli,Joost P. M. van Meerwijk

Issue Date: 27 April 2018

Cite this article:

Cécile Apert,Paola Romagnoli,Joost P. M. van Meerwijk. IL-2 and IL-15 dependent thymic development of Foxp3-expressing regulatory T lymphocytes[J]. Protein Cell, 2018, 9(4): 322-332.

URL:

https://academic.hep.com.cn/pac/EN/10.1007/s13238-017-0425-3
https://academic.hep.com.cn/pac/EN/Y2018/V9/I4/322

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