The roles of Mesp family proteins: functional diversity and redundancy in differentiation of pluripotent stem cells and mammalian mesodermal development

doi:10.1007/s13238-015-0176-y

Protein Cell

2015, Vol. 6

Issue (8) : 553-561 https://doi.org/10.1007/s13238-015-0176-y

REVIEW

The roles of Mesp family proteins: functional diversity and redundancy in differentiation of pluripotent stem cells and mammalian mesodermal development

Qianqian Liang¹,Chen Xu¹,Xinyun Chen¹,Xiuya Li¹,Chao Lu¹,Ping Zhou¹,Lianhua Yin¹,Ruizhe Qian¹,Sifeng Chen¹,Zhendong Ling^2,^*(

),Ning Sun^1,^*(

)

1. Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Research Center on Aging and Medicine, Shanghai Medical College, Fudan University, Shanghai 200032, China
2. Department of Surgery, The Branch of Shanghai No. 1 Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200081, China

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Abstract

Mesp family proteins comprise two members named mesodermal posterior 1 (Mesp1) and mesodermal posterior 2 (Mesp2). Both Mesp1 and Mesp2 are transcription factors and they share an almost identical basic helix-loop-helix motif. They have been shown to play critical regulating roles in mammalian heart and somite development. Mesp1 sits in the core of the complicated regulatory network for generation of cardiovascular progenitors while Mesp2 is central for somitogenesis. Here we summarize the similarities and differences in their molecular functions during mammalian early mesodermal development and discuss possible future research directions for further study of the functions of Mesp1 and Mesp2. A comprehensive knowledge of molecular functions of Mesp family proteins will eventually help us better understand mammalian heart development and somitogenesis as well as improve the production of specific cell types from pluripotent stem cells for future regenerative therapies.

Keywords Mesp transcription factor pluripotent stem cells cardiovascular differentiation somitogenesis

Corresponding Author(s): Zhendong Ling,Ning Sun

Issue Date: 05 August 2015

Cite this article:

Qianqian Liang,Chen Xu,Xinyun Chen, et al. The roles of Mesp family proteins: functional diversity and redundancy in differentiation of pluripotent stem cells and mammalian mesodermal development[J]. Protein Cell, 2015, 6(8): 553-561.

URL:

https://academic.hep.com.cn/pac/EN/10.1007/s13238-015-0176-y
https://academic.hep.com.cn/pac/EN/Y2015/V6/I8/553

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