Specification of functional neurons and glia from human pluripotent stem cells

doi:10.1007/s13238-012-2086-6

Prot Cell

2012, Vol. 3

Issue (11) : 818-825 https://doi.org/10.1007/s13238-012-2086-6 PMID: 23143871

REVIEW

Specification of functional neurons and glia from human pluripotent stem cells

Yuan Jiang, Mei-Jiang Zhang, Bao-Yang Hu(

)

State Key Laboratory of Reproductive Biology, Key laboratory of Translational Stem Cell Research, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China

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Abstract

Human pluripotent stem cells (PSCs) such as embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) hold great promise in regenerative medicine as they are an important source of functional cells for potential cell replacement. These human PSCs, similar to their counterparts of mouse, have the full potential to give rise to any type of cells in the body. However, for the promise to be fulfilled, it is necessary to convert these PSCs into functional specialized cells. Using the developmental principles of neural lineage specification, human ESCs and iPSCs have been effectively differentiated to regional and functional specific neurons and glia, such as striatal gama-aminobutyric acid (GABA)-ergic neurons, spinal motor neurons and myelin sheath forming oligodendrocytes. The human PSCs, in general differentiate after the similar developmental program as that of the mouse: they use the same set of cell signaling to tune the cell fate and they share a conserved transcriptional program that directs the cell fate transition. However, the human PSCs, unlike their counterparts of mouse, tend to respond divergently to the same set of extracellular signals at certain stages of differentiation, which will be a critical consideration to translate the animal model based studies to clinical application.

Keywords pluripotent stem cells embryonic stem cells induced pluripotent stem cells neural stem cell regenerative medicine cell transplantation

Corresponding Author(s): Hu Bao-Yang,Email:byhu@ioz.ac.cn

Issue Date: 01 November 2012

Cite this article:

Yuan Jiang,Mei-Jiang Zhang,Bao-Yang Hu. Specification of functional neurons and glia from human pluripotent stem cells[J]. Prot Cell, 2012, 3(11): 818-825.

URL:

https://academic.hep.com.cn/pac/EN/10.1007/s13238-012-2086-6
https://academic.hep.com.cn/pac/EN/Y2012/V3/I11/818

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