Polycomb chromobox Cbx2 enhances antiviral innate immunity by promoting Jmjd3-mediated demethylation of H3K27 at the <i>Ifnb</i> promoter

doi:10.1007/s13238-018-0581-0

Protein Cell

2019, Vol. 10

Issue (4) : 285-294 https://doi.org/10.1007/s13238-018-0581-0

RESEARCH ARTICLE

Polycomb chromobox Cbx2 enhances antiviral innate immunity by promoting Jmjd3-mediated demethylation of H3K27 at the Ifnb promoter

Donghao Sun, Xuetao Cao, Chunmei Wang(

)

Department of Immunology and Center for Immunotherapy, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100005, China

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Abstract

Polycomb chromobox (CBX) proteins regulate gene transcription by maintaining chromatin states, which guide a variety of biological processes. Now, epigenetic regulation of innate immune response is an emerging field. However, the role of CBX proteins in innate immunity remains unclear. We confirmed that the expression of CBX family proteins, especially Cbx2, was decreased in macrophages upon viral infection, and then we investigated the role of Cbx2 in the antiviral immune response. Silencing or knockdown of Cbx2 in macrophages inhibited virus-induced production of IFN-β. Furthermore, heterozygous Cbx2 knockout were susceptible to VSV challenge. Mechanistically, Cbx2 binds to and recruits Jmjd3 to the Ifnb promoter, leading to demethylation of H3K27me3 and increased transcription of IFN-β. Together, our study reveals a nontraditional function of a Cbx protein and adds new insight into the epigenetic regulation of antiviral innate immunity.

Keywords Cbx2 Jmjd3 interferon beta innate immunity

Corresponding Author(s): Chunmei Wang

Issue Date: 12 April 2019

Cite this article:

Donghao Sun,Xuetao Cao,Chunmei Wang. Polycomb chromobox Cbx2 enhances antiviral innate immunity by promoting Jmjd3-mediated demethylation of H3K27 at the Ifnb promoter[J]. Protein Cell, 2019, 10(4): 285-294.

URL:

https://academic.hep.com.cn/pac/EN/10.1007/s13238-018-0581-0
https://academic.hep.com.cn/pac/EN/Y2019/V10/I4/285

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