SUMOylation of RIG-I positively regulates the
type I interferon signaling

doi:10.1007/s13238-010-0030-1

Protein Cell

2010, Vol. 1

Issue (3) : 275-283 https://doi.org/10.1007/s13238-010-0030-1 PMID: 21203974

Research articles

SUMOylation of RIG-I positively regulates the type I interferon signaling

Zhiqiang Mi¹,Jihuan Fu²,Yanbao Xiong²,Hong Tang²,

1.Center for Molecular Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China；Key Laboratory of Infection and Immunity of Chinese Academy of Sciences, Institute of Biophysics, Beijing 100101, China; 2.Key Laboratory of Infection and Immunity of Chinese Academy of Sciences, Institute of Biophysics, Beijing 100101, China;

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Abstract Retinoic acid-inducible gene-I (RIG-I) functions as an intracellular pattern recognition receptor (PRR) that recognizes the 5’-triphosphate moiety of single-stranded RNA viruses to initiate the innate immune response. Previous studies have shown that Lys63-linked ubiquitylation is required for RIG-I activation and the downstream anti-viral type I interferon (IFN-I) induction. Herein we reported that, RIG-I was also modified by small ubiquitin-like modifier-1 (SUMO-1). Functional analysis showed that RIG-I SUMOylation enhanced IFN-I production through increased ubiquitylation and the interaction with its downstream adaptor molecule Cardif. Our results therefore suggested that SUMOylation might serve as an additional regulatory tier for RIG-I activation and IFN-I signaling.

Keywords RIG-I SUMOylation type I interferon innate immunity

Issue Date: 01 March 2010

Cite this article:

Zhiqiang Mi,Yanbao Xiong,Jihuan Fu, et al. SUMOylation of RIG-I positively regulates the type I interferon signaling[J]. Protein Cell, 2010, 1(3): 275-283.

URL:

https://academic.hep.com.cn/pac/EN/10.1007/s13238-010-0030-1
https://academic.hep.com.cn/pac/EN/Y2010/V1/I3/275

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